Bactericidal Activity of Octenidine to Various Genospecies of Borrelia burgdorferi, Sensu Lato Spirochetes in Vitro and in Vivo
Journal Title: Polish Journal of Microbiology - Year 2017, Vol 66, Issue 2
Abstract
The aim of our studies was to invent a reliable method for detection of bactericidal activity of disinfectants against Borrelia burgdorferi in suspension (in vitro) and in cell line cultures (in vivo). In the suspension method, 0.01 % octenidine at 20°C and 35°C was bactericidal to Borrelia afzeli; Borrelia garini, B. burgdorferi sensu stricto after 5 minutes treatment. Increase of the temperature to 35°C speed up the bactericidal effect to 1 minute. The bactericidal action of octenidine towards B. burgdorferi spirochetes growing in fibroblasts was less effective and needed a longer time to kill them than in the suspension.
Authors and Affiliations
Stanisława Tylewska-Wierzbanowska, Urszula Roguska, Grażyna Lewandowska, Tomasz Chmielewski
Keywords
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- EP ID EP251334
- DOI 10.5604/01.3001.0010.7874
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