Bacteriological Profile of Acute Pyogenic Meningitis in Pediatric Age Group from a Tertiary Care Hospital of East Delhi
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 3
Abstract
Background and Objectives Laboratory surveillance of causative microorganism is crucial to formulate rational empirical treatment and preventive strategies for potentially fatal acute pyogenic meningitis (APM). This study was aimed to identify the causative microorganism of APM in children admitted in a tertiary care hospital of east Delhi. Materials and Methods Cerebrospinal fluid (CSF) was collected from 300 suspected cases of APM and subjected to cytology, gram staining, biochemical analysis and culture. Every fifth CSF sample was also subjected to antigen detection by latex agglutination test (LAT) for Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Escherichia coli, group B Streptococcus and Taqman probe-based real time polymerase chain reaction (RTPCR) for S. pneumoniae, H. influenzae and N. meningitidis. Simultaneously, blood culture was also done from all these 300 cases. Result From CSF, 19 microorganisms were isolated in which hospital-acquired multidrug resistant Acinetobacter baumannii (9) was most common. S. pneumoniae, H. influenzae, group B Streptococcus, E. coli, Staphylococcus aureus and Klebsiella were also identified as a causative agent of APM. LAT detected microorganism in nine culture negative samples, whereas RTPCR detected two additional microorganisms which were missed by LAT. Conclusion This study highlights the emergence of MDR A. baumannii as a common agent of APM in hospital setting and emphasise on judicious use of antibiotics to prevent resistance.
Authors and Affiliations
Mishra Prakash K, Singh Narendra P, Batra Prerna, Kaur Iqbal R
Keywords
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