Bacteriological profile of gram negative nosocomial isolates from intensive care units and their antibiogram in a tertiary care hospital of South India
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2018, Vol 4, Issue 4
Abstract
Introduction Nosocomial infection is a key factor in determining clinical outcomes among patients admitted in intensive care units Studies on nosocomial infections in ICUs found that respiratory tract infections blood stream infections urinary tract infections and soft tissue infections are the common nosocomial infections in ICUs These infections are more commonly caused by Gram negative isolates These organisms isolated are highly resistant to antibiotics Early recognition of bacteria and appropriate antimicrobial therapy are essential for controlling infection preventing the morbidity and improve the quality of lifeObjectives To find out the profile of Gram negative bacteria causing nosocomial infection in patients admitted in intensive care units To know the antibiotic susceptibility pattern of the nosocomial isolatesMaterials and Methods A total of 192 culture positive samples were taken from various clinical specimens The organisms were identified by Gram staining cultural characteristics and a battery of biochemical tests Drug susceptibility was performed on the isolates by Kirby Bauers disk diffusion method Results A total of 202 organisms were isolated from 192 various clinical samples Respiratory tract infection 76 396 was the most common infection in Intensive care units The number of Gram positive isolates was 60 297 142 703 Gram negative organisms were isolated Among the Gram negative isolates Escherichia coli 46 228 was the most frequently isolated organism followed by Klebsiella species 34168 Highest occurrence of nosocomial infections was observed in CCU 52 271 followed by ICCU 48 25Among Gram negative bacilli minimum resistance was seen against imipenem 268followed by piperacillin tazobactam 451 and amikacin 479 Conclusion This study shows that Gram negative bacteria were the major cause of infections in intensive care units The most common isolates were Ecoli followed by Klebsiella sp and Acinetobacter sp For Gram negative isolates the most effective antibiotics were imipenem followed by piperacillin tazobactam and amikacin Appropriate antibiotic utilization in Intensive Care Units is crucial not only in ensuring an optimal outcome but also in preventing multidrug resistant bacteriaKeywords Nosocomial isolates Gram negative bacteria Antibiotic susceptibility pattern
Authors and Affiliations
Zarrin Afroz, Basavaraj C. Metri, Faisal N. Gilani, Jyothi P.
Keywords
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- EP ID EP485886
- DOI 10.18231/2581-4761.2018.0053
- Views 64
- Downloads 0
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