Basic examination of an automated coagulation analyzer, Coapresta 2000, and introduction to 24-hour emergency service
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 3
Abstract
Recently, in addition to accuracy and reliability, clinical laboratories have also been under pressure to produce results with speed around the clock, A novel automated coagulation analyzer, Coapresta 2000 (CP2000: Sekisui Medical Co., Ltd.), has enabled them to meet those requirements. In order to start a 24-hour emergency service of coagulation and fibrinolysis tests, we conducted a basic examination of the following tests: prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, hepaplastin, antithrombin Ⅲ (AT Ⅲ), fibrin degradation products (FDP), D-dimer and soluble fibrin monomer complex (SFMC) with the CP2000. In the CP2000, these test items were investigated for within-run and between-day reproducibility, and the linearity of test results. The coefficient of variation of within-run assays was less than 3.0% while that of between-day was less than 4.7% in each test item. The linear response ranges were 0 to 750 mg/dL in fibrinogen, 0 to 13μg/mL in FDP, 0.3 to 120μg/mL in D-dimer, and 17 to 100μg/mL in SFMC. A comparison study was conducted between the evaluation method (Coapresta 2000) and the present method (Coagrex-800, Sysmex Corporation). Except for APTT, significant correlations were observed in all test items (correlation coefficients were all higher than 0.993, p<0.001). We concluded that Coapresta 2000 was able to provide 24-hour emergency service in coagulation and fibrinolysis tests.
Authors and Affiliations
Yuji Oikawa
Keywords
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