Biochemical Investigation of Hepatotoxic effects of Antiretroviral Drugs on Wistar Albino Rats
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 4
Abstract
Hepatotoxic effects of antiretroviral drugs (Stavudine, Lamivudine, and Nevirapine) on wistar albino rats were investigated using biochemical parameters; Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and Total protein (TP). ALT and AST activities were estimated by the methods of Reitman and Frankel, using enzyme assay kits and TP was determined by Biuret method using total protein kits. There was no significant difference in the mean values of ALT, AST and TP in Stavudine treated wistar albino rats. However, there was significant difference in the mean values of AST (25.00± 2.00) and ALT (29.25± 3.19) P ≤ 0.05 in Lamivudine treated wistar albino rats. Nevirapine treated wistar albino rats showed significant difference in AST, ALT, and TP; (37.50 ± 5.81,38.75 ±3.19 and 3.75± 0.08) respectively P ≤ 0.05, when compared with the various controls; (20.25 ± 2.00,16.75 ±3.19 and 5.40± 0.10) respectively. The results indicated that Nevirapine was the most hepatotoxic, followed by Lamivudine and least in Stavudine.
Authors and Affiliations
Sule O. J , Godwin J , Nnopu I. A
Keywords
Related Articles
- EP ID EP114665
- DOI -
- Views 120
- Downloads 0
Antihypertensive Effects of [i]Gmelina Arborea[/i] Roxb (Verbenaceae) Leaves Crude Aqueous Extract Fractions in Wistar Rats
The present work was carried out to investigate the antihypertensive properties of fractions Gmelina arborea aqueous extract, one of the medicinal plants used in the treatment of arterial hypertension. Fractions of Gmeli...
The Impact of Patient-Prescriber Interaction Group Discussions on Injection Prescribing in Public and Private Primary Health Care Facilities in Kinondoni District, Dar es Salaam, Tanzania
The use of medicine in treating diseases is an integral component of health care, and currently practicing physicians are being challenged by coping with rapidly changing pharmacologic treatments. There is evidence that...
Undergraduate Pharmacology: Student’s view – A Questionnaire Study
Pharmacology, a branch of medicine is progressing by leaps and bounds. But the place and status of pharmacology in the medical curriculum is hazy. Medical students decry the way it is taught, its examinations, its useful...
A Study of Cardiac Parameters using Impedance Plethysmography (IPG) in Healthy Volunteers
Impedance plethysmography is non – invasive technique to measure blood flow in any part of the body like heart (Impedance Cardiography), arteries or veins. As only heart rate and blood pressure is not sufficient to acces...
Expression of TGF-β1 During Fracture Repair in Ovariectomized Rats with Therapy of Cissus Quadrangularis Extract
This study aims to determine the osteogenic potential of Cissus quadrangularis extract based on its ability to increase the expression of TGF beta-1 in the case of osteoporotic fractures. This study used fourty female ra...