Biochemical Study of the Endothelial function in persons living at High Altitude in Saudi Arabia
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 2
Abstract
The aim of this study was to investigate the biochemical effect of high altitude on modulation of the adaptive response of endothelial functions in persons’ living at high altitude in Saudi Arabia. Materials and Methods: this study included 90 apparently healthy individuals, composed of 2 groups: High altitude group; 45 apparently healthy male volunteer subjects from Abha city, (2,200 meters above sea level). Sea level group; 45 apparently healthy control male volunteer subjects from Makkah. Laboratory measurements for all subjects were performed including: Fasting blood sugar, kidney and liver function tests, and plasma lipid profile. In addition, parameters of vascular endothelial functions including: Nitric Oxide (NO) in the form of serum nitrite and nitrate (NO2-/NO3-), serum endothelin-1 (ET-1) and vascular cell adhesion molecule (VCAM-1) were also measured. Results: Measurements confirmed higher levels of ET-1 in high altitude subjects compared with those at sea level (P < 0.001). Serum VCAM-1 in high altitude subjects are higher compared with those at sea level (P = 0.015). Our results also, confirmed higher levels of NO in high altitude subjects compared with those at sea level (P = 0.003). conclusion: our data suggest that chronic hypoxia at high altitude may lead to higher circulating concentrations of these important vasoactive compounds (VCAM-1, ET-1 and NO), either as a direct result of hypoxia or as adaptive response to chronic high-altitude exposure. This process could imply a potential role for the measurement of these compounds in the prognostic evaluation of patients with cardiovascular diseases.
Authors and Affiliations
Mohamed Abd-Ellatif, Abdullah S. Assiri, Ayyub Patel, Essam M. Nour Eldein, Maha F. Hamoudah, Shirin H Teama, Waleed N. Hassan
Keywords
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