BIODISTRIBUTION OF DOXORUBICIN-LOADED SUCCINOYL CHITOSAN NANOPARTICLES IN MICE INJECTED VIA INTRAVENOUS OR INTRANASAL ROUTES
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
Chitosan (Chi) is an extremely promising natural biopolymer with remarkable potency for the development of drug and vaccine delivery nanosystems. Various Chi derivatives are used to form nanoparticles (NPs) with unique properties. However, the efficacy of the therapy delivered by Chi NPs depends significantly on NP biodistribution in the body. The aim of this study was the analysis of biodistribution of NPs formed by succinoyl Chi and loaded with doxorubicin (SCNPDOX). We compared the distribution of free DOX and SCNP-DOX after intravenous (i.v.) and intranasal (i.n.) delivery into tumour-bearing mice. Distribution of DOX and SCNP-DOX was comparable after i.v. injection while they differed significantly after i.n. instillation.
Authors and Affiliations
Anastasia A. Zubareva, Tatyana S. Shcherbinina, Valery P. Varlamov, Elena V. Svirshchevskaya
Keywords
Related Articles
- EP ID EP73412
- DOI 10.15259/PCACD.19.18
- Views 93
- Downloads 0
Studies on the Dyeing of Chitin and Chitosan with pre-metallised Dyes at Neutral pH
Both 1:1 pre-metallised acid dyes and pre-coppered direct dyes, but not 1:2 pre-metallised acid dyes, have been shown to readily dye chitin and chitosan from neutral dyebaths. With the 1:1 pre-metallised acid dyes the ad...
ISOLATION AND PURIFICATION OF INTRACELLULAR CHITOSANOLYTIC ENZYMES OF Mucor circinelloides
Application of the authors’ new, two-step (bacitracin affinity chromatography and gel filtration on Sephadex G-100) method of purification of M. circinelloides intracellular enzymes gave the preparation with the relative...
PLA MICROGRANULES USED AS CARRIERS OF ACTIVE SUBSTANCES PREPARED BY EMULSIFICATION IN CHITOSAN SOLUTION
The aim of research was the preparation of poly(lactide) and chitosan composite of spherical structures by emulsyfication of both polymers solutions. This resulted in fabrication of PLA microstructures (mPLA) suspended i...
INFLUENCE OF A CHOSEN AUXILIARY SUBSTANCE ON THE PROPERTIES OF HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEX WITH CHITOSAN
The wide range of pH and viscosity of the investigated preparations shall enable selection of a gel with optimum pH and rheological properties. The value of pH of a gel have swollen is greatly influenced by the content o...
POLYMER BIOCOMPOSITES USED IN BEDSORES TREATMENT
Investigations are presented in the preparation of composite dressing material based on two biopolymers -chitosan and sodium alginate with the addition of sulfanilamide as medication designed for the healing of bedsores....