Biomarkers for early diagnosis of sepsis-associated acute kidney injury
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 11
Abstract
Sepsis-associated acute kidney injury (SA-AKI) is a heterogeneous syndrome caused by direct mechanisms of sepsis or indirect mechanisms induced by sepsis treatment, leading to kidney damage. Current research of SA-AKI focuses on the application of novel diagnostic biomarkers, including proenkephalin A 119-159, soluble thrombomodulin, hepcidin, urinary angiotensinogen, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, cystatin C, kidney injury molecule-1, liver-type fatty acid-binding protein, and cell cycle arrest proteins. These biomarkers are related to the pathogenesis of SA-AKI. This paper summarizes the biological functions, basic and clinical research status of these early diagnostic markers, and their role in the treatment of critically ill SA-AKI patients, aiming to assist in the early identification, diagnosis, and treatment of SA-AKI in clinical practice.
Authors and Affiliations
GE Xin Department of Emergency and Critical Care Medicine, Wuxi Ninth Hospital Affiliated to Soochow University, Wuxi, Jiangsu 214062, China
Keywords
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- EP ID EP751723
- DOI 10.13429/j.cnki.cjcr.2024.11.001
- Views 17
- Downloads 0
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