Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-II
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2024, Vol 5, Issue 2
Abstract
This literature review analyzes the results from studies applying conditioned medium and extracellular vesicles derived from the mesenchymal stem cell secretome to numerous disease states in animal and human in-vivo models. Information about the conditions treated and the observed benefits and side-effects of these therapeutics are discussed. Ongoing clinical trials applying conditioned medium and extracellular vesicles, recommended future research and limitations of cell-free strategies are addressed. Findings demonstrate that the mesenchymal stem cell secretome holds promise as an effective treatment for numerous disease states. This manuscript is a companion piece to “Part 1: Bioregenerative Applications of the Human Mesenchymal Stem Cell-Derived Secretome,” included in this issue, which contains background information about stem cells and mesenchymal stem cells, their limitations in-vivo and the advent of cell-free strategies as a viable alternative for disease treatment.
Authors and Affiliations
Matthew Keagle1, Vincent S Gallicchio2*
Keywords
Related Articles
- EP ID EP735866
- DOI https://doi.org/10.46889/JRMBR.2024.5203
- Views 33
- Downloads 0
Utilizing Adipose Tissue-Derived Stem Cell Strategies for Obtaining Regeneration of Respiratory Tract Fistulas-A Systematic Review
Fistula of the respiratory tract represent an aberrant communication or passage among the respiratory system as well as the digestive tract or the nearby organs. They might originate congenitally or more commonly, iatr...
Potential Mesenchymal and Dental Pulp Stem Cell Usage for Regeneration of Dentine and Its Complications
Tooth decay is an extremely common problem throughout the nation. As individuals pass the age of 20 years old, 90% have had some form of tooth decay. Along with this, more than 1 in 4 people have untreated tooth decay in...
The Use of Stem Cell Therapy in the Treatment of Autism Spectrum Disorder
Research on the use of stem cell therapy in regenerative medicine has shown great potential in the treatment of neurological disorders. Specifically, mesenchymal stem cells, adult stem cells from the umbilical cord and e...
The Future Role of Mesenchymal Stem Cells in Tissue Repair and Medical Therapeutics: Realities and Expectations
Mesenchymal Stem Cells (MSCs); which were first described by Alexander Fridenstein in the 1960s; are heterogeneous, non-hematopoietic, adult multipotent stromal progenitor cells that are capable of self-renewal and dif...
The Jounced Entrails-Intestine in COVID-19
Coronavirus disease 2019 (COVID-19), initiated by contemporary coronavirus is a pandemic which engenders severe respiratory disease. SARS-CoV-2 preponderantly transmits through airborne particles and mammoth respirator...