Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-II
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2024, Vol 5, Issue 2
Abstract
This literature review analyzes the results from studies applying conditioned medium and extracellular vesicles derived from the mesenchymal stem cell secretome to numerous disease states in animal and human in-vivo models. Information about the conditions treated and the observed benefits and side-effects of these therapeutics are discussed. Ongoing clinical trials applying conditioned medium and extracellular vesicles, recommended future research and limitations of cell-free strategies are addressed. Findings demonstrate that the mesenchymal stem cell secretome holds promise as an effective treatment for numerous disease states. This manuscript is a companion piece to “Part 1: Bioregenerative Applications of the Human Mesenchymal Stem Cell-Derived Secretome,” included in this issue, which contains background information about stem cells and mesenchymal stem cells, their limitations in-vivo and the advent of cell-free strategies as a viable alternative for disease treatment.
Authors and Affiliations
Matthew Keagle1, Vincent S Gallicchio2*
Keywords
Related Articles
- EP ID EP735866
- DOI https://doi.org/10.46889/JRMBR.2024.5203
- Views 59
- Downloads 0
Advancing Extracellular Vesicle Therapeutics into Clinical Trials for Central Nervous System Disorders
In December 2023, the US Food and Drug Administration released a draft guidance document titled “Potency Assurance for Cellular and Gene Therapy Products Draft Guidance for Industry” for public comment [1]. Potency assay...
Celiac Disease and the Potential of Stems Cells as Treatment
Celiac disease is characterized by having a broad spectrum of clinical presentations ranging from asymptomatic cases to classical gastrointestinal manifestations of disease and cases of severe progression in refractory c...
Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-I
Mesenchymal stem cells hold many therapeutic benefits in treating diverse disease states, but autologous requirements, high costs, lack of standardization and other factors limit their widespread application. Additionall...
3D Bioprinting for Tissue Engineering Amidst the Century Cataclysm
The coronavirus is one of our modernistic day’s major universal, human defies. The human brain is planned to prefer the present-day and underrate the future. That triggers it hard to prohibit disasters like pandemics. Nu...
The Jounced Entrails-Intestine in COVID-19
Coronavirus disease 2019 (COVID-19), initiated by contemporary coronavirus is a pandemic which engenders severe respiratory disease. SARS-CoV-2 preponderantly transmits through airborne particles and mammoth respirator...