Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-I
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2024, Vol 5, Issue 2
Abstract
Mesenchymal stem cells hold many therapeutic benefits in treating diverse disease states, but autologous requirements, high costs, lack of standardization and other factors limit their widespread application. Additionally, researchers have discovered that many mesenchymal stem cell in-vivo benefits originate from their paracrine factors. Therefore, cell-free therapeutics, including mesenchymal stem cell-derived conditioned medium and extracellular vesicles have been suggested as alternative bioregenerative therapies. This literature review summarizes mesenchymal stem cell application, the benefits of cell-free strategies and the components of its secretome. This manuscript is a companion piece to “Part 2: Bioregenerative Applications of the Human Mesenchymal Stem Cell-Derived Secretome,” included in this issue, which contains the results of in-vivo studies applying the conditioned medium and extracellular vesicles to human and animal models, ongoing clinical trials, limitations to cell-free strategies and future directions for the wide-scale adoption of these therapies.
Authors and Affiliations
Matthew Keagle1, Vincent S Gallicchio2*
Keywords
Related Articles
- EP ID EP735865
- DOI https://doi.org/10.46889/JRMBR.2024.5202
- Views 8
- Downloads 0
Patient Perspectives on Use of Stem Cells to Treat Osteoporosis
Osteoporosis is a systemic skeletal disease leading to increased risk of fragility fractures. These fractures lead to significant patient morbidity, increased mortality and substantial health and social care costs. Th...
After Effects of COVID-19 and Repair of Lungs
Lung disease is the most effected organ in patients. Corona (CoV) targets the lungs and causes death of millions of patients across the globe. There has been increasing burden in lung associated disease due to the pand...
A Gout Flare Caused by the Administration of Platelet Rich Plasma: A Clinical Case
The therapy with Platelet Rich Plasma (PRP) administered in degenerated or injured musculoskeletal tissues is a new and promising regenerative treatment option. Traditionally, it is considered that as PRP represents an a...
Expression of Neuron Specific Neuronal Nuclei Protein (NeuNNP) by AAV2 Shows Diagnosis Ability in Spinal Cord Injury Using Neural Stem Cells
Fibroblast Growth Factor (FGF) shows promising therapy for Spinal Cord Injury (SCI). Neural stem transplantation has been on the role implementing tactics to repair SCI. Considering the hostile hypoxia condition in SCI...
Human CO Model of Creutzfeldt - Jakob Disease (CJD) Evaluates the Effect of Putative Drugs on Prion Accumulation
Creutzfeldt Jakob Disease (CJD) is incurable and fatal neurodegenerative disease. The treatment in human is cell based models for prion disease. An induced pluripotent stem cell based models of human cerebral organ has s...