自发性癫痫大鼠脑内海马<br /> Ⅲ型电压门控性钠通道N亚型表达上调<br />
Journal Title: Science Paper Online - Year 2006, Vol 1, Issue 4
Abstract
[目的] 对照研究自发性癫痫大鼠（SER）和正常Wistar大鼠（WTC）脑内Ⅰ、Ⅱ、Ⅲ型钠通道α亚基mRNAs与蛋白表达情况。[方法] 提取枕叶皮质、齿状回及海马CA1和CA3区组织总RNA，应用逆转录-聚合酶链反应（RT-PCR）及建立限制性内切酶图谱检测Ⅰ、ⅡA、ⅡN、ⅢA和ⅢN的表达，应用免疫荧光定位与表达α3亚基ⅢN蛋白。[结果] SER枕叶皮质、齿状回及海马CA1 和CA3区总钠通道的表达略高于WTC，但均无显著差异（P>0.05），SERⅢ型钠通道在海马的表达高于WTC （P<0.01），酶切图谱显示ⅢN型钠通道表达水平有明显上调。[结论] SER脑内海马Ⅲ型电压门控性钠通道N亚型表达上调。
Authors and Affiliations
Na Yu , Feng Guo , Wa Du
Keywords
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