C-reactive protein in cerebrospinal fluid: An evaluative and correlative study
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 6, Issue 1
Abstract
Objectives: This study aimed to test Cerebro Spinal Fluid and importance of C Reactive. Protein in Meningitis cases. CSF analysis is done on suspected meningitis patients and biochemical values of CSF was studied and compared with the C Reactive Protein levels. Methods: A prospective study included 55 patients admitted to people s college of medical sciences, Bhopal, between October 2015 to April 2017. Samples from patients suspected of meningitis will be collected based on history and clinical examination by respective clinicians. CSF will be subjected to routine microscopy and analysed for colour, turbidity, proteins, glucose, cells etc. All samples will be subjected to CRP analysis by latex agglutination system. All CRP positive patients will be correlated with routine analysis and biochemical values of CSF. Results: Out of 55 patients, 23(41.8%) were CRP-Negative and 32(58.2%) were CRP-Positive. Out of 20 cases of bacterial meningitis, 14 cases were CRP Positive and out of 22 cases of viral meningitis, 17 cases were CRP-positive while out of 13 non infective cases, 12 cases had CRP-Negative and only one case had 0.6 mg/dl C-reactive protein. It indicates highly significant association between C Reactive protein level in CSF and meningitis. Viral meningitis has less than 0.6 mg/dl CRP level in most of the cases. All non infective cases had lower values of CSF protein while viral and bacterial cases of meningitis had higher level of CSF protein. It shows significant association between Meningitis and CSF protein. CRP level in the viral meningitis cases were found to be less than 0.6mg/dl in CSF. Higher CRP values is associated with bacterial meningitis cases. Conclusion: CRP is found to be an important inflammatory marker for distinguishing between bacterial and viral meningitis and when it is evaluated along with CSF biochemical and microscopic findings, the results were more accurate.
Authors and Affiliations
Upasana Uniya, Reetesh Kumar Gujar, Pratyush Jha
Keywords
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