Carcinogenic viruses in etiopathogenesis of skin cancers in patients after organ transplantation
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
The latest literature report specifies multifactoral etiology of skin cancer in population of patients after organs transplats. Carcirogenic viruses are one of etiopathogenesis components. Viruses of a vital meaning for skin oncogenesis are called Human papillomavirus – HPV, Human herpesvirus 8 – HHV8 i Merkel cell polyomavirus – MCV. Report on connections exisisting between viruses HPV and skin cancers in the population of patients after organs transplants confirms clinical connection between viruses papillas and cancers centres occuring in similar locations and more frequent appearance of attributes characteristic for HPV infection within the limits of changes in the type of Squamous cell carcinoma (SCC). What’s more, coexisting of viruses papillas and SCC is more often noticed in the population of organ recipients than in the population of healthy people. It is not confirmed yet that any specific correlation between subtypes of HPV and greater frequency of morbidity in skin cancers really exist. However, in the population of organ recipients infections of different types of HPV are found within the limits of cancers centres in the case of SCC (63%) as well as in basal cell carcinoma-BCC (55%). DNA of HPV was also fund in healthy parts of organ recipients skin (92-94%).HHV8 is also an oncogenic viruse that influences the development of lymphoma. Infection of that virus may cause ocuuring of Kaposi’s sarkoma, which is one of the most frequent types of cancer appearing in population of patients treating by long – term immunosuppression in particular geographical zones. MCV, which belongs to the group called Polyomaviriade, owes a particular meaning in etiopathogenesis of Merkel cell carcinoma – MCC. It is a rare cancer derived from neuroendocrine cells of the basic layers of epidermie. For over 30 years it was supposed that correlation between viruses and skin cancers in population of organ recipient exist. Knowledge of the total viruses influence on skin cancers allows to widen the spectrum of anti – cancers prevention in the future.
Authors and Affiliations
Maria Luiza Piesiaków, Beata Imko-Walczuk, Karolina Osiecka, Marta Kiełbowicz, Alicja Dębska-Ślizień
Keywords
Related Articles
- EP ID EP220728
- DOI -
- Views 180
- Downloads 0
NET i NEToza – nowe zjawisko w immunologii
Neutrofile są jednymi z pierwszych komórek układu odpornościowego pojawiającymi się w miejscu wystąpienia infekcji, reprezentując jeden z najskuteczniejszych i najszybszych sposobów walki organizmu z patogenami. Niedawn...
Retigabine – a new antiepileptic drug with a different mechanism of action
Retigabine belongs to a new generation of antiepileptic drugs. Its mechanism of action is different from that previously known. Retigabine opens potassium channels of subfamily Kv 7, especially Kv 7.2 and Kv 7.3. The dru...
Morganella sp. rods – characteristics, infections, mechanisms of resistance to antibiotics
The Morganella genus is one member of the tribe Proteae, which also includes the genera Proteus and Providencia. These bacteria are commonly present in the environment. Morganella sp. rods are known to be a causative ag...
Crossed renal ectopia: can it be a diagnostic problem?
Crossed renal ectopia (C-RE) is a rare congenital anomaly in which both kidneys are located unilaterally. The crossed kidney is situated on the side opposite to its ureteral orifice and usually lies below the normal kidn...
Rola białka YKL-40 w procesie nowotworowym
YKL-40 jest białkiem sekrecyjnym, wydzielanym m.in. przez komórki nowotworowe oraz makrofagi towarzyszące guzom. Ze względu na homologię strukturalną białko to zaklasyfikowano do rodziny chitynaz CLP (chitinase-like prot...