Cardiovascular and Antioxidant Effects of the Methanol Extract From the Stem Bark of Erythrina Senegalensis DC (Fabaceae)
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2013, Vol 3, Issue 4
Abstract
The present study was undertaken to investigate the cardiovascular and the in vitro antioxidant activities of the methanol extract of the stem bark of Erythrina senegalensis (EMES), a plant used traditionally in Cameroon against arterial hypertension. The cardiovascular effects of EMES (11-44 mg/kg) were evaluated in vivo on normotensive rat arterial blood pressure and on rabbit’s electrocardiogram (5.5- 55 mg/kg) while the in vitro study (10-10 - 1 mg/ml) on myocardial contractile performance was evaluated on rat isolated heart. The antioxidant activities of EMES (1-1000 μg/ml) were investigated on 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2)-induced haemolysis, nitric oxide (NO) production, as well as its reducing power. The intravenous injection of EMES provoked in anaesthetized normotensive rats, a dose dependent immediate reduction in arterial hypertension. The mean arterial blood pressure dropped by 11.29, 19.84 and 24.42 % at respective doses of 11, 22 and 44 mg/kg. When administered intravenously in rabbit EMES significantly reduced the heart rate, amplitudes of P wave and QRS complex while significantly increasing the duration of the QT interval. EMES exhibited a concentration dependent reducing power, antiradical activity on DPPH (EC50 of 46.9 μg/ml) and a significant (p<0.001) antioxidant effect on H2O2-induced haemolysis. EMES also substantially increase NO production. In conclusion, EMES exert immediate hypotensive effect which might be attributed to its negative inotropic and chronotropic effects. Its in vitro antioxidant activities could be beneficial for the treatment of cardiovascular ailments.
Authors and Affiliations
A. D. Atsamo , S. A. Néné-Bi , K. L. Kouakou , K. C. Fofie , P. Nyadjeu , J. Y. Datté , A. Kamanyi , T. B. Nguelefack
Keywords
Related Articles
- EP ID EP115230
- DOI -
- Views 105
- Downloads 0
Effect of Antioxidants Supplementation at Refrigeration Temperature on Sperm Motion Characteristics and Membrane Integrity of Sirohi Buck Semen
The aim of this study was to determine the effects of addition of various antioxidants at different levels, viz. glutathione reduced, glutathione oxidized, vitamin C and vitamin E to the extender on sperm viability, acro...
Effect of Supplemental Feed Additives on the Performance of Broilers
Poultry farmers are usually desirous of getting their birds to reach market weight within the shortest possible period. While this could be dependent on various factors such as the type or breed of the day-old-chick, the...
Effect of Excessive Green Tea versus Fluoride and Caffeine on Body Weight and Serum Thyroid Hormones in Male Mice
Green tea is a worldwide used beverage rich in fluoride and caffeine. To study the effect of excessive green tea intake versus fluoride and caffeine on body weight and serum thyroid hormones in male mice. Also, to confir...
Evaluation of Clinical Symptoms and Associated Factors in the Drug-Induced Toxicity in Patients Referred to Hospital
Today, Drug Problem with the global expansion has become a burden on society due to high drug production, increased purity and low price of these materials. The aim of this study was to investigate the clinical manifesta...
Diabetic Neuropathy in Black Sub-Saharian Africa Subject: Clinical and Electromyographic Fealures
Diabetic neuropathy occurs in more than 60% of diabetic’s populations. The aim of our study wasto describe clinical and electromyography characteristics of diabetic neuropathy in a Senegalese black diabetic population (S...