Study of the Chemopreventive Effects of Zingiber Officinale Roots Against Aspartame Induced Testicular Toxicity in Rat Model
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 5
Abstract
Infertility is one of the major health problems in life, and approximately 30% of this problem is due to male factors. Research carried out in last few decades has validated several such claims of use of traditional medicine plants. Zingiber officinale (Z. officinale) roots is commonly used as culinary spice and used medicinally for its antioxidant and androgenic activities. The aim of the present study was to evaluate the chemoprotective effect of Z. officinale roots against aspartame induced rat testicular toxicity. The chosen dose of aspartame was adjusted to 0.2ml/ 25g b.wt. and was given three times per week for 12 weeks. Ginger aqueous extract were adjusted to 500mg/kg and were given three times per week for 12 weeks. Aspartame caused a marked rise in serum testosterone, LH and FSH hormones level. Concerning oxidative stress and antioxidant defense system, aspartame group pretreated with ginger extract successfully ameliorated testes reduced glutathione level, glutathione-s-transferase and catalase activities compared to aspartame treated group which give inverse results. However, while elevated lipid peroxidation was noticed in aspartame treated rats, pretreatment with ginger extract produced a detectable decrease in lipid peroxidation level. The natural plant components may have chemopreventive effect against aspartame that may be cause testicular toxicity. However, further clinical studies are required to assess the safety and benefits of ginger root in human beings.
Authors and Affiliations
W. G. Hozayen , H. A. Soliman , H. S. Abou Seif
Keywords
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