Study of Possible Colonic Mucosal and Motility Changes in Experimental Acetic Acid Induced Colitis in Male Albino Rats under the effect of Oral Barley Administration in Comparison with Venlafaxine
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 9
Abstract
The current study was conducted on 40 male albino rats subjected to acetic acid 4% induced colitis except the negative control group I .Its scope concerned histological and functional colonic evaluation of pretreatment with barely extract (1g/kg), venlafaxine (32mg/kg) and their combination orally administered daily for one week before experimental induction of colitis and extended three successive days after induction; groups III, IV and V respectively. Those were compared to non treated acetic acid colitis as a positive control; group II. The study ranked the significant protection afforded by combination therapy group V followed by venelafaxine group IV and lastly barely extract group when compared to non treated injured acetic acid induced colitis group II. Our results were evidenced by colonic ulcer index scoring, microscopic histological examination, biochemical estimation of colonic myeloperoxidase activity and functional motility ex vivo studies. It can be concluded that venlafaxine combined with barley extract had the best impact on colonic mucosal and motility state. Furthermore, being a non starch polysaccharide, tryptophan and trace elements source, barley extract could retrieve the anti-inflammatory activity and protective effect of monoamine reuptake inhibitor venlafaxine.
Authors and Affiliations
I. E. Darwish , M. M. Hala , S. O. Amany
Keywords
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