Diabetic Neuropathy in Black Sub-Saharian Africa Subject: Clinical and Electromyographic Fealures
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2015, Vol 5, Issue 8
Abstract
Diabetic neuropathy occurs in more than 60% of diabetic’s populations. The aim of our study wasto describe clinical and electromyography characteristics of diabetic neuropathy in a Senegalese black diabetic population (Senegal). This was a cross-sectional study of 68 neuropathic type 2 diabetic patients with 56.8years mean age. Clinical examination, Visual Analog Scale, Neuropathy Symptom Score, Disability Neuropathy Score and electro neuromyography were used to characterize neuropathy. Mean duration of diabetes was 8.7 years and mean glycosylated hemoglobin9%. Motor neuron deficit was found in one patient. The main sensory disorders were paresthesia (97%), neuropathic pain (94%), and hyperesthesia (44%). Cramps were found in 45.5% and tendon reflex abnormalities in 63.2% of cases. Tachycardia (52.9%), intestinal transit disorders (42.6%) were the most common symptom of autonomic nervous system neuropathy. High blood pressure (p=0.05) and sex (p<0.001) were statistically associated with autonomic nervous system neuropathy. The electro neuromyography (EMG) showed axonal sensorimotor neuropathy (50.7%), demyelinating sensorimotor neuropathy (70%), axonal damage (27%) and myelin damage (20.6%). Axonal neuropathy was statistically correlated to diabetes’ treatment (p<0.001) and demyelinating neuropathy with diabetes follow-up. Peripheral neuropathy was the most common type of polyneuropathy (42.6%). The EMG abnormalities were not statistically correlated with duration of diabetes and glycosylated hemoglobin (p>0.05). Diabetic neuropathy in our series is a multi variate symptom with usually mixed type. Its risks’ factors were still poorly known. Studies on larger series would better characterize it.
Authors and Affiliations
M. Touré, D. Dièdhiou , A. Basse , M. hassimi , L. B. Seck , B. Abdoulaye , M. M. Ndiaye , S. N. Diop , L. Gueye
Keywords
Related Articles
- EP ID EP89812
- DOI -
- Views 95
- Downloads 0
Hepatoprotective and Antioxidant Activities of Tribulus Terrestris
Tribulus terrestris L. has been used in folk medicine throughout history. The present study examined the acute toxicity of the total ethanolic extract of T. Terrestris followed by investigation of the hepatoprotective ac...
Effect of Sex and Age on Normal Microfloral population dynamics of Gastrointestinal Tract in Grasscutters (Thryonomys swinderianus)
The grasscutter meat is widely recognized as a source of animal protein in many West African countries, Particularly, Ghana, Benin, and Cote D’voire. Despite the apparent potential of the grasscutter, attempts made to do...
Effect of Tephrosia Vogelii Hook.f. Leave Extracts on the Isolated Heart of Toad: Hypothesis of the Mechanism of Action
The ichtyotoxic plants contain substances, which could present a danger to the consumers of caught fish with it. The isolated heart of toad was used in this experimentation according to the modified method of Langendorff...
The Enzymatic and Hormonal Reactions of Cockerels Exposed to Crude Oil Contaminted Diets
An experiment was carried out at the Teaching and Research Farm of Rivers State University of and Technology, Port Harcourt to evaluate the enzymatic and hormonal reactions cockerels exposed to crude oil contaminated die...
Attenuation of Allodynia and Hyperalgesia by the Leaf Extracts of Clerodendrum Formicarum in Rat Model of Diabetic Neuropathic Pain
Painful neuropathy is the most common and debilitating complication of diabetes and results in allodynia and hyperalgesia. Hyperglycemia clearly plays a key role in the development and progression of diabetic neuropathy....