Comparative Study of the Haematology and Serum Biochemistry of Male Wistar Rats Treated with Chloroquine and Artesunate
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 8
Abstract
The comparative effect of Chloroquine and Artesunate; two drugs commonly used in the prophylaxis and chemotherapy of malaria on the haematology and serum biochemistry of male wistar rats was studied. The rats (n=15) weighing between 150-220g were divided equally into 3 groups; A, B and C. Group A served as control, B received chloroquine at 20mg/kg body weight for 3 days while C received Artesunate at 4mg/kg body weight on the first day followed by 2mg/kg body weight thereafter for six consecutive days. Hematological and selected serum biochemical parameters were assessed. Varying degrees of derangements were noticed in the experimental groups. The haematology findings reveal that there was intravascular haemolysis, leucocytosis with significant (p<0.05) decrease in neutrophils in both groups. The serology reveals an increased serum creatinine level which was significantly (p<0.05) higher in chloroquine treated rats. Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) levels in both groups were elevated. The drugs therefore have varying grades of cytotoxicity to RBC, bone marrow depressing effect, hepatotoxicity and nephrotoxicity. It is therefore recommended that these chemical agents despite their long existence in the treatment of malaria should be used with caution as indiscriminate use and/or overdose have deleterious side effects.
Authors and Affiliations
O. O. Omotosho , M. A. Adebiyi , M. O. Oyeyemi
Keywords
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