The Effect of Various doses of Vitamin C on some Physiological Parameters in Rabbits Following Xylazine Anaesthesia
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2015, Vol 5, Issue 5
Abstract
The effects of various doses of vitamin C on physiological parameters following xylazine anaesthesia was evaluated in rabbits. Thirty six animals were divided into six equal groups (A-F). Groups A and B served as controls for vitamin C and xylazine treatments alone respectively; while groups C-F received varying doubling doses of vitamin C prior to xylazine anaesthesia and their effects on temperature (T), respiratory rates (RR) and heart rates (HR) were measured. Pre-treatment with vitamin C (30mg/Kg, per os) prior to xylazine (4mg/Kg, i.m) showed an increase in the onset and duration of action of anaesthesia and lowered respiratory rate by 33%, but did not alter rectal temperature. Vitamin C pre-medication at 60 - 240mg/Kg prior to anaesthesia induced increase of 0.3 - 8% in rectal temperature and decrease in heart rate of 19 - 40%. Vitamin C at rates of 60mg/Kg and 120mg/Kg increased RR by 3-39%. It is therefore concluded that vitamin C alters some clinical parameters as well as sleeping time in rabbits under xylazine anesthesia. At lower doses Vitamin C produces CNS stimulation, while at higher doses it produces CNS depression which is advantageous when higher doses of xylazine are required for prolonged surgical procedures.
Authors and Affiliations
G. O. Egwu , G. D. Mshelia , S. Sanni , P. A. Onyeyili , C. P. Mshelia , N. Elelu
Keywords
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