Correlation of Serum ALP Activity with them Healing Process of Femoral Fractures in Rats Used Cissus Quadrangularis Extract as Therapy
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 1
Abstract
The purpose of this study was to find out corellate value of serum ALP activity with the process of fracture healing in rat with therapy Cissus quadrangularis extract. This study used 18 male white rats (Rattus Norwegicus) age of 12 weeks. After 1 week of adaptation, all rats were treated femoral dexter osteotomy under aseptic conditions. Then, reposition of femoral dexter fractures with intramedullary pin fixation. The rats model were evenly randomly divided into three groups at 2nd weeks after surgery: group I treated with normal diet, group II with normal diet + CaCo3 supplement 150 mg/day, group III with normal diet + Cissus qudrangularis extract 500 mg / day per oral. Furthermore, the treatment was carried out for 4 weeks. At the end of the experiment (6th weeks after surgery), the blood samples were taken directly from canthus orbitalis dexter for alkaline phosphatase analysis. The data were analyzed by One Way Anova using SPSS for Windows program. The results indicated that ALP activity was significantly decreased ( p < 0,05). The more complete the fracture healing process, ALP activity the closer to normal value. The conclusion is the serum total ALP actvity have a positive correlation with the process of fracture healing and could be used to determine the progress of fracture healing of the surgically treated fractures.
Authors and Affiliations
I. S. Yudaniayanti , L. Nangoi , J. Soepraptini
Keywords
Related Articles
- EP ID EP136403
- DOI -
- Views 85
- Downloads 0
Hepatoprotective Effect of Glycyrrhiza Glabra in Carbon Tetrachloride-Induced Model of Acute Liver Injury
Acute liver injury is a serious state of extensive damage of liver tissue caused by various reasons. Certain medicinal plants had been used to cure some liver diseases. The present study was done to evaluate the hepatopr...
Modulatory Activity of Aqueous Extract of Carica Papaya Seed on carbon Tetra-Chloride-Induced Hepatotoxicity in Wistar Rats
The effect of aqueous extract of ripe Carica papaya seed on liver function enzymes of CCl4 induced hepatotoxic liver was studied. Thirty (30) adult Wister rats were randomly divided into five (5)experimental groups. (n=6...
Preliminary Study of Hypoglycaemic and Hypolipidemic Activity of Aqueous Root Extract of Ricinus Communis in Alloxan-Induced Diabetic Rats
Since diabetes mellitus is a major risk factor that leads to secondary conditions like cardiovascular disease, management of the condition include controlling other risk factors that may lead to secondary conditions in a...
Diabetic Neuropathy in Black Sub-Saharian Africa Subject: Clinical and Electromyographic Fealures
Diabetic neuropathy occurs in more than 60% of diabetic’s populations. The aim of our study wasto describe clinical and electromyography characteristics of diabetic neuropathy in a Senegalese black diabetic population (S...
Plasma Total Protein, Serum Calcium and Inorganic Phosphate Levels in Nigerian Horses with Natural Piroplasmosis
The objectives of this study were to determine alterations in plasma total protein, serum calcium and phosphorus levels in horses with natural piroplasmosis. Knowledge of these alterations, enable clinicians decide on th...