CENTRAL ANTINOCICEPTIVE EFFECT OF DIFFERENT EXTRACTS OF SARACA ASOCA SEEDS ASSESSED USING HOTPLATE AND TAIL IMMERSION METHODS  

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 10

Abstract

The stem bark of Ashoka (Saraca asoca) plant has been traditionally used for a number of therapeutic purposes including anti-inflammatory activities. It has been described in ancient Ayurvedic texts as an analgesic also but rampant use of its stem bark has affected the plant population although its seeds are available in plenty. This research effort aims to examine the central analgesic effect of acetone, methanol and aqueous extracts of the powder of Asoka seeds to validate its antinociceptive properties described in the literature. Apart from the standard pharmacognosy and phyto-chemical examination, acute toxicity studies were carried out on all the extracts before assessing the central analgesic effect using the standard techniques of hot plate and tail immersion methods. Morphine Sulphate was used as the standard drug in both these cases. During phytochemical analysis, flavonoids, polyphenols, tannins and saponins were found in the plant extracts while no significant morbidity or any mortality was noticed during the toxicity studies. All the extracts exhibited significant central analgesic effect at doses of 300 mg/kg and 500 mg/kg as compared to the control group, the antinociceptive efficacy being greater at the higher drug dose. The highest analgesic effect was observed in case of aqueous extract, followed by acetone extract and the lowest in case of methanol extract. The therapeutic efficacy at higher dosage of aqueous extract was comparable to but lower compared to the standard drug. However, the analgesic effect of the drug extracts persisted for a longer time than the standard drug, validating its comparable and sustained analgesic effect. 

Authors and Affiliations

Mradu Gupta, Saumyakanti Sasmal, Arup Gupta

Keywords

Related Articles

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF PAMABROM AND PARACETAMOL IN SYNTHETIC MIXTURE 

A new, simple, precise, accurate and selective high performance thin-layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of pamabrom and paracetamol in a synthetic mix...

PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY FROM NERIUM OLEANDER AND EVALUVATE THEIR PLANT MEDIATED NANOPARTICLE SYNTHESIS  

Phytochemical and antibacterial activity of essential oils obtained from Nerium oleander leaf with the help of three different extracts like ethanol, Methanol, and acetone. In this aqueous leaf extracts confirms the pres...

EVALUATION OF ANTIMICROBIAL AND ANTI-HISTAMINE ACTIVITY OF THE AERIAL PARTS OF TEPHROSIA PURPUREA L.  

Tephrosia purpurea (Fabaceae) has been used as a medicinal plant in all over India. This plant is a much branched perennial herb. Roots are given orally against any type of poisoning such as snakebite and the aerial part...

THE ROLES OF CLINICAL PHARMACY IN REDUCING MEDICATION ERRORS 

Potential activation of clinical pharmacist role is of great importance in reducing the medication errors which are a well- known problem in hospital. The medication errors could be prescribing errors, dispensing errors,...

ASPIRIN AND NICOTINIC ACID AS TWO FACES OF SAME COIN IN THE TREATMENT OF DYSLIPIDEMIA 

Globally cardiovascular diseases are believed to be the no.1 cause of death. According to the current estimates of World Health Organisation, approximately one-third of all deaths (16.7 million people) around the globe...

Download PDF file
  • EP ID EP131077
  • DOI 10.7897/2230-8407.041021
  • Views 104
  • Downloads 0

How To Cite

Mradu Gupta, Saumyakanti Sasmal, Arup Gupta (2013). CENTRAL ANTINOCICEPTIVE EFFECT OF DIFFERENT EXTRACTS OF SARACA ASOCA SEEDS ASSESSED USING HOTPLATE AND TAIL IMMERSION METHODS  . International Research Journal of Pharmacy (IRJP), 4(10), 94-98. https://europub.co.uk/articles/-A-131077