CENTRAL ANTINOCICEPTIVE EFFECT OF DIFFERENT EXTRACTS OF SARACA ASOCA SEEDS ASSESSED USING HOTPLATE AND TAIL IMMERSION METHODS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 10
Abstract
The stem bark of Ashoka (Saraca asoca) plant has been traditionally used for a number of therapeutic purposes including anti-inflammatory activities. It has been described in ancient Ayurvedic texts as an analgesic also but rampant use of its stem bark has affected the plant population although its seeds are available in plenty. This research effort aims to examine the central analgesic effect of acetone, methanol and aqueous extracts of the powder of Asoka seeds to validate its antinociceptive properties described in the literature. Apart from the standard pharmacognosy and phyto-chemical examination, acute toxicity studies were carried out on all the extracts before assessing the central analgesic effect using the standard techniques of hot plate and tail immersion methods. Morphine Sulphate was used as the standard drug in both these cases. During phytochemical analysis, flavonoids, polyphenols, tannins and saponins were found in the plant extracts while no significant morbidity or any mortality was noticed during the toxicity studies. All the extracts exhibited significant central analgesic effect at doses of 300 mg/kg and 500 mg/kg as compared to the control group, the antinociceptive efficacy being greater at the higher drug dose. The highest analgesic effect was observed in case of aqueous extract, followed by acetone extract and the lowest in case of methanol extract. The therapeutic efficacy at higher dosage of aqueous extract was comparable to but lower compared to the standard drug. However, the analgesic effect of the drug extracts persisted for a longer time than the standard drug, validating its comparable and sustained analgesic effect.
Authors and Affiliations
Mradu Gupta, Saumyakanti Sasmal, Arup Gupta
Keywords
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- EP ID EP131077
- DOI 10.7897/2230-8407.041021
- Views 82
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