Changes in serum zinc, magnesium and copper in sickle cell patients: A case study in Jos, Nigeria
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 5
Abstract
This research was designed to understudy trace elements (zinc, magnesium and copper) implications in 120 subjects (60 sickle cell anemia patients and 60 non-sickle cell individuals) attending clinic at Bingham University Teaching Hospital, Jos, Plateau State, Nigeria. Their blood samples were collected and their sera used for the estimation of zinc, magnesium and copper using inductively coupled Plasma-optical emission spectrometry technique. Their Mean ± SEM values for zinc, magnesium and Copper in 60 sickle cell anemic patients are 64.5 ± 5.9 μg/dL, 5.7 ± 1.7 mg/ L and 2.1 ± 0.1 mg/L, respectively. While those of normal or nonsickle cell patients i.e. control were 94.5 ± 4.8 μg/dL, 16.8 ± 2.9 mg/L and 1.9 ± 0.1 mg/L, for zinc, magnesium and copper, respectively). The result showed significant decrease (p < 0.05) in zinc and magnesium levels of sickle cell patients when compared with non- sickle cell subjects (control). Copper which have been implicated in antagonizing zinc for the same binding site showed no significant change in sickle cell patients when compared with the Hb-AA control group. Growth retardation factors (height and weight) significantly decreased (p < 0.05) in sickle cell patients when compared with control group. These results confirm that zinc and magnesium are deficient in sickle cell patients hence, trace element supplementation may be necessary in the management of sickle cell disease as it will arrest oxidative stress and per-oxidation with resultant stability of erythrocyte membranes as well as reduction in the rate of hemolysis and other symptoms often noticed in sickle cell anemic patients.
Authors and Affiliations
Asanga Edet Effiong
Keywords
Related Articles
- EP ID EP198430
- DOI -
- Views 83
- Downloads 0
Study on the utilization of different mode of access of drug information service in a tertiary care hospital
Aim and Objective: The study was conducted to compare drug information service utilization after a new mode of access to drug information centre was introduced. Materials and Methods: This prospective study was conducted...
Synthesis of antimicrobial active benzimidazole-2-thioate derivatives of 2-mercaptobenzimidazole
Synthesis of antimicrobial active benzimidazole-2-thioate derivatives of 2-mercaptobenzimidazoleA facile, green, efficient and one pot synthetic method for biological active benzimidazole-2-thioate derivatives comprising...
Synthesis and spectral characterization of esomeprazole sodium Polymorphic form
Regulatory authorities throughout the world require that all possible crystalline forms of the same active drug compound be synthesized and characterized as completely as possible. There is thus a continuing need to prep...
Correlation of the structural changes in OCT with functional visual field defects among Primary Open angle Glaucoma patients
Glaucoma is characterized by progressive degeneration of retinal ganglion cells and their axons that leads to nerve fiber layer loss, optic disc cupping, and consecutive glaucomatous visual field changes. Study is done i...
Galantamine as benzofuro-benzazepine alkaloid used in cognition and dementia
Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Galantamine is in a class o...