CHANGES OF ANTIMITOCHONDRIAL ANTIBODY LEVELS IN PATIENTS WITH CHRONIC HEPATITIS C DURING TREATMENT AND THEIR ASSOCIATION WITH CLINICAL-LABORATORY AND EPIDEMIOLOGICAL DATA
Journal Title: Гепатологія - Year 2017, Vol 38, Issue 4
Abstract
Analyzing autoantibodies level of the patients with chronic hepatitis C who were on antiviral therapy with interferon drugs, the increase in the number of patients with elevated amount of antimitochondrial antibodies (AMA) was established on the 12th week of therapy. Also, the connection between clinical data (especially complaints that are specifi c for autoimmune disease disorders - arthralgia, myalgia) and concomitant pathology of autoimmune genesis with increased AMA in patients’ blood was detected. Th ese patients during antiviral therapy also showed connection between habitat (mainly rural), level of activity (positive relationship), the degree of fi brosis (inverse relationship), viral load (positive relationship) and alleles of IL-28V (mainly CT / TT, CT / TG).
Authors and Affiliations
M Chemych, A Lishnevska
Keywords
Related Articles
- EP ID EP251877
- DOI -
- Views 94
- Downloads 0
PECULIARITIES OF NON-SPECIFIC BRANCH OF IMMUNITY IN PERIPHERAL BLOOD IN LIVER ECHINOCOCCOSIS BEFORE AND AFTER TREATMENT
Th e paper presents the results of the evaluation of non-specifi c response of the immune system in the peripheral blood of patients with liver echinococcosis. Signifi - cant changes in non-specifi c response of the im...
ORIGINAL METHOD OF INFLUENCE ON THE LEVEL OF PROINFLAMMATORY CYTOKINE TNF-ALPHA ACTIVITY
A new personifi ed method of infl uence on activity condition of pro-infl ammatory cytokine – tumor necrosis factor alpha by means of intradermal autoleukocyte immunization has been described in the art...
Клініко-епідеміологічні особливості перебігу хронічного вірусного гепатиту В у донорів крові, обстежених на HBsAg у південному регіоні України за період 2007-2016 роки
Transfusion infections, including hepatitis B virus (HBV), are a major problem in blood transfusions. In the middle of 1980s, HBsAg testing was performed with ELISA for control of blood donors in non-endemic, associated...
IMMUNOLOGICAL PROGNOSIS OF LIVER ENCEPHALOPATHY IN PATIENTS WITH ACUTE HEPATITIS B
Th e article presents the method of investigation of T-lymphocyte activation in patients with acute hepatitis B (HBV) to prognosticate possible development of liver encephalopathy. Th e condition...
MINERAL HOMEOSTASIS IN FUNCTIONAL DISORDERS OF THE LIVER IN SOLDIERS OF ANTITERRORIST OPERATION WITH BRAIN INJURY OF MILD AND MODERATE SEVERITY
Th e article is dedicated to the study of interconnection of brain metabolism impairment in craniocerebral injury of mild and moderate severity in soldiers of antiterrorist operation with changes...