Characteristics of NAT+ blood donors screened for transfusion-transmitted infectious markers in Hainan
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 7
Abstract
Objective To explore the epidemiological characteristics of voluntary blood donors with enzyme-linked immuno-sorbent assay (ELISA) negative and nucleic acid testing (NAT) positive in Hainan from 2012 to 2022, so as to provide reference for developing rational blood screening strategies. Methods The screening results for transfusion-transmitted disease markers in 1 161 042 blood samples in Hainan from 2012 to 2022 were retrospectively analyzed. All samples have been measured twice by ELISA and once by NAT. Statistical methods were used to analyze the proportion of ELISA negative and NAT positive (ELISA-/NAT+ ) among voluntary blood donors and its relation with factors including gender, age, ethnicity and region. Results Among the voluntary blood donors in Hainan from 2012 to 2022, the overall proportion of ELISA-/NAT+ was 0.19% (2 151/1 161 042), and the difference was statistically significant (P<0.05). The ELISA-/NAT+ rate in hepatitis B virus (HBV) DNA, hepatitis C virus (HCV) RNA, human immunodeficiency virus (HIV) RNA and non-discriminating reactive (NDR) was 0.10%, 0.000 3%, 0.000 4% and 0.09% respectively. The ELISA-/NAT+ rate of voluntary blood donors varied among different age groups and gradually increased with age (P<0.05). The ELISA-/NAT+ rate of male donors (0.22%, 1 729/795 032) was significantly higher than that of female donors (0.12%, 422/366 010, P<0.05). The ELISA-/NAT+ rate of Han blood donors was significantly lower than that of Li and Miao blood donors (P<0.05). The ELISA-/NAT+ rate was the highest of 0.32% (301/94 046) in the eastern region, followed by 0.30% (341/113 783) in western region, and 0.16% in both southern and northern region, which also presented a significant difference (P<0.05). Conclusion The ELISA-/NAT+ rate of voluntary blood donors in Hainan fluctuated from 2012 to 2022, which was related to factors such as age, gender, ethnicity and region.
Authors and Affiliations
Yongli ZHANG, Hui HAN
Keywords
Related Articles
- EP ID EP742817
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.07.014
- Views 89
- Downloads 0
Potential value of differential expression of CDC42 gene in adult and umbilical cord blood reticulocytes
Objective To explore critical regulatory genes in the hemoglobin switch process by analyzing transcriptomic data from the GSE6236, GSE17639 and GSE35102 datasets. Methods The mRNA expression profiles of the three dataset...
Establish deferral criterion for HIV serological testing in blood donors
Objective To establish deferral criterion of HIV ELISA (enzyme-linked immunosorbent assay) and electrochemiluminescence immunoassay(ECLIA) by using receiver operating characteristic curve(ROC) method to screen HIV reacti...
Expert consensus on testing of killer-cell immunoglobulin-like receptor genes
The killer-cell immunoglobulin-like receptor(KIR) gene family exhibits complex genetic diversity. In addition to allele level polymorphisms, KIR genes show extra diversity at haplotype content as well as copy number vari...
Influence of sample hemolysis on ELISA test results in blood screening laboratory
Objective To analyze the effect of sample hemolysis on ELISA test results in blood screening laboratory, so as to determine the acceptable tolerance of hemolysis specific to laboratory test items and detection system, an...
Desalination effect on FⅧ components: a compartive study among 5 desalination methods
Objective To compare the desalination effects of five desalination methods and their effects on the components for human coagulation factor Ⅷ(FⅧ), and provide reference for selection of protein desalination methods. Meth...