CHOROIDAL THICKNESS IN PATIENTS OF MATURITY ONSET DIABETES OF THE YOUNG WITH POSITIVE GLUCOKINASE GENE MUTATION
Journal Title: Kocatepe Medical Journal - Year 2022, Vol 23, Issue 3
Abstract
OBJECTIVE: The aim of this study was to compare the choroi-dal thickness (CT) of patients diagnosed with maturity onset di-abetes of young (MODY) with positive glucokinase (GCK) gene mutation with healthy individuals. MATERIAL AND METHODS: Thirty patients (MODY group) and and 30 healthy individuals (control group) whose diagnosis of MODY was confirmed by looking for GCK gene mutation but without diabetic retinopathy were included in this study. The control group was selected to be compatible with the MODY group for age, sex, refractive error and axial length. The choroidal thickness was measured at the fovea in the right eye of the patients, 1.5 mm and 3 mm away to the fovea in nasal and temporal side using RTVue-100 Fourier-domain optical coherence tomography (OCT). RESULTS: MODY diagnosis time was 4.1±5.8 years (range; 0- 17 years). While the average HBa1c levels were 5.1 (range:4.4-6.2, reference range:4-6), none of the patients were diagnosed with diabetic retinopathy. The mean subfoveal CT was 370.09 ± 86.66 μm in the MODY group and 354.44 ± 76.70 μm in the control group (p=0.456). The choroidal thickness at nasal 1.5 mm (300.75 ± 67.02 and 296.13 ± 73.45 μm respectively, p=0.672), nasal 3 mm (184.56 ± 45.53 and 192.94 ± 57.63 μm respectively, p=0.485), temporal 1.5 mm (325.16 ± 59.41 and 299.59 ± 67.81 μm respectively, p=0.093), and temporal 3 mm (261.88 ± 43.30 and 256.75 ± 50.83 μm respectively, p=0.582) did not show statistically significant changes. CONCLUSIONS: Although there have been lots of studies which examined the effects of diabetis on choroidal changes in the literature, this study is the first to specifically evaluate choroidal thickness in patients with MODY. The CT may not be affected in MODY patients without diabetic retinopathy. This can be attributed to the fact that the patients with MODY are young, the duration of MODY is short and diabetes regulation is good.
Authors and Affiliations
Osman ÇELİKAY, Tolga BİÇER, Mustafa KÖŞKER, Naciye KABATAS, Erman ÇAKAL, Canan GÜRDAL
Keywords
Related Articles
- EP ID EP706862
- DOI https://doi.org/10.18229/kocatepetip.905627
- Views 83
- Downloads 0
RELATIONSHIP BETWEEN PLASMA 25 HIDROXY VITAMIN D3 LEVEL AND HELICOBACTER PYLORI INFECTION IN CHILDREN
OBJECTIVE: The severity of the Helicobacter pylori (H.pylori) infection and the presence H.pylori related diseases are affected by host, bacterial and environmental factors. In this study it is aimed to show relationship...
SATISFACTION LEVELS AND SURGICAL RESULTS OF PATIENTS WHO HAD NESBIT CORPOROPLASTY DUE TO PENILE CURVATURE
OBJECTIVE: In this study, it is aimed to evaluate the satisfaction level and surgical results of patients who were performed Nesbit operation due to penile curvature. MATERIAL AND METHODS: Patients who were performed Ne...
CLINICAL AND DEMOGRAPHIC CHARACTERISTICS OF FAMILIAL MULTIPLE SCLEROSIS IN THE INNER AEGEAN REGION
OBJECTIVE: Multiple sclerosis (MS) is a common autoimmune demyelinating disease of the central nervous system (CNS). In this study, it was aimed to collect patients with MS retrospectively, to compare the characteristics...
THE EFFECT OF ANTERIOR INTERBODY CAGE BORON APPLICATION IN RABBIT VERTEBRAE ON BONE FUSION AND FUSION QUALITY
OBJECTIVE: Our aim in this study was to demonstrate the effectiveness of hydroxyapatite (HA) and Boron compounds in operations using an Anterior Lumbar Interbody Fusion (ALIF). MATERIAL AND METHODS: In the study, 18 mal...
NEONATAL CARE OF NEWBORN BABY ON MECHANICAL VENTILATION
Mechanical ventilation for respiratory support is one of the most effective methods for mortality and morbidity in neonatal intensive care units. Skin care, pain management, airway safety, humidification, protection of b...