Chronic Progressive External Ophthalmoplegia A Rare Case Report
Journal Title: PARIPEX-Indian Journal of Research - Year 2015, Vol 4, Issue 5
Abstract
Chronic progressive external ophthalmoplegia (CPEO), also known as progressive external ophthalmoplegia (PEO), is a type of eye disorder characterized by slowly progressive inability to move the eyes and eyebrows.[1] It is often the only feature of mitochondrial disease, in which case the term CPEO may be given as the diagnosis. In other people suffering from mitochondrial disease, CPEO occurs as part of a syndrome involving more than one part of the body, such as Kearns-Sayre syndrome. Occasionally CPEO may be caused by conditions other than mitochondrial diseases. A woman aged 20years presented with history of drooping of both eyelids started 07 years back . No history of fatiguability , fluctuations in drooping of eyelids. No H/O consanguinity. Neurological examination showed moderate bilateral ptosis and marked limitation of conjugate gaze in all direction. Serum acetylcholine receptor antibody was negative. Neostigmine test was negative. MRI brain normal. Repetitive nerve stimulation test showed no decremental response both at rest and post exercise. Histopathological examination of biopsy specimen from left quadriceps revealed Ragged red fibres on Modified Gomari Trichome (MGT) stain ,suggestive of mitochondrial myopathy - CPEO.
Authors and Affiliations
Dr. C. Sreenivasulu, Dr. G. Shaul Hameed, Dr. T. Vinil
Keywords
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