CLINICAL COURSE OF NON-ALCOHOLIC STEATOHEPATITIS IN COMORBIDITY WITH CHRONIC KIDNEY DISEASE OF I-III STAGES
Journal Title: Гепатологія - Year 2017, Vol 38, Issue 4
Abstract
Objective − to investigate the clinical features of NASH course and CKD of I-III stages studying the frequency and intensity of the leading clinical and biochemical syndromes of NASH. Materials and methods. We examined 105 patients with NASH: 52 patients with NASH and obesity of I degree (1 group), 53 patients with NASH, comorbid obesity of I degree and CKD of I-III stages (group 2). To determine the dependence of NASH course on CKD presence, a group of patients was randomized by age, sex, and degree of obesity. Males constituted 48 individuals, females – 57 with average age being 45.8 ± 3.81 years.Th e functional condition of the liver and kidneys was determined by the generally accepted list of enzyme activity, markers of pigment and nitrogen metabolism, lipidograms, ionograms, proteinograms, calculation of de Ritis coeffi cient, and glomerular fi ltration rate. Structural changes in the liver and kidney parenchyma were determined by ultrasonography. In order to quantify the changes in liver echogenicity we used the method of echodensitometry with calculation of the hepatorenal index. Results. Our investigation showed that the clinical course of non-alcoholic steatohepatitis in comorbidity with obesity and CKD is characterized by high frequency and intensity of clinical (asthenic-vegetative, dyspeptic, hemorrhagic, cholestatic and endocrine disorders, splenomegaly, and hepatomegaly) and biochemical (cytolytic, cholestatic, mesenchymal infl ammatory syndrome and syndrome of hepatic-cellular insuffi ciency) syndromes. Th e comorbid course of NASH with CKD is characterized by a high degree of hepatic steatosis and a higher diagnostic value threshold for hepatorenal index.
Authors and Affiliations
O Khukhlina, A Antoniv
Keywords
Related Articles
- EP ID EP251878
- DOI -
- Views 115
- Downloads 0
Плазмовий остеопонтін як біомаркер фіброзу печінки у дітей з хронічним гепатитом В
13 было определение уровня плазменного остеопонтина (ОПН) у детей, в зависи- мости от вирусной нагрузки, активности воспалительного процесса и степени фиброза в печени. Установлено, что уровень данного гликопептида у де...
COMPARATIVE CHARACTERISTICS OF THE EFFECTIVENESS OF DIFFERENT HEPATITIS C TREATMENT REGIMENS
The article presents the results of HCG treatment with diff erent regimens of therapy: interferon drugs and drugs of direct antiviral action.
Персоніфікований метод посилення ефективності противірусної терапії хронічного гепатиту В
У статті розглядається оригінальний метод посилення ефективності про- тивірусної терапії хронічного гепатиту В. Для цього на тлі противірусної те- рапії препаратом з групи аналогів нуклеоз(т)идів внутрішньошкірно про- во...
CELL IMMUNOMODULATING THERAPY OF EXTRA-HEPATIC MANIFESTATIONS OF CHRONIC VIRAL HEPATITIS B AND C AND AUTOIMMUNE HEPATITIS
Clinical examples proving effi cacy of immunomodulating therapy in the form of intradermal immunization with inactivated autoleukocytes have been presented in the article. It is seen from the examples that amo...
AGE AND GENDER PECULIARITIES OF BIOCHEMICAL INDICATORS, LIPID AND CYTOKIN BLOOD PROFILES IN NONVIRAL CHRONIC HEPATITIS PATIENTS
Currently, an increase in the incidence of nonviral chronic hepatitis is observed in Ukraine and worldwide. Pro and anti-infl ammatory cytokines play an active role in the pathogenesis of chronic hepatitis, acting as m...