Clinical genetics of lung cancer
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 1
Abstract
Every year more than 1 million people all over the world die because of lung cancer. In addition to smoking and other environmental carcinogens, factors responsible for the disease include constitutional DNA alterations. A characteristic feature of markers of a genetic predisposition to lung cancer, is relatively slightly increased risk of developing cancer among carriers of DNA alteration. Very promisive markers of severe risk of lung cancer are biochemical markers like the concentration of certain micro elements. Studies performed in our Center clearly indicate that selenium levels > 80 μg/l are associated with strongly reduced risk of lung cancer. The examination of selenium concentration in blood serum can be very useful marker in screening for early detection of lung cancer by preselection of individuals with high probability of finding cancer by computerized tomography (CT). Very important is also identification of additional predictive markers for adjustment of treatment regimens depending on the status of specific markers, such as the presence or absence of specific mutations.
Authors and Affiliations
Marcin Lener, Tomasz Grodzki, Jan Lubiński
Keywords
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