Clinical Profile of Alcoholic Liver Disease and Its Association with Pattern of Alcohol Consumption and Prognostic Markers
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Background: Alcoholic Liver Disease (ALD) Is A Severe Complication Related To Chronic And Excessive Alcohol Consumption And Includes A Spectrum Of Hepatic Lesions: Fatty Liver To Chronic Hepatitis. The Liver Injury Is A Complex Process, But The Quantity, Duration And Type Of Alcohol Intake Are The Most Important Risk Factors For ALD And Correlated Well With The Prognostic Markers. Early Acceptance Of Alcohol Abuse By The Patient And The Vigilance Of The Physician’s Toward Diagnosis Of Alcohol-Related Problems Is Requisite To Prevent Complications And Decreases Mortality. Aim: Present Study Aimed At Investigating The Association Of Type, Amount And Duration Of Alcohol Consumption With Clinical Profile Of Alcoholic Liver Disease And Comparison With The Prognostic Markers. Methods: The CrossSectional Study Design With Total 245 Patients Of ALD Were Selected In 23 To 67 Years Age Group, From Pt. Jawaharlal Nehru Memorial Medical College, Department Of Medicine, Raipur (C.G.) (Pt. JNM Medical College, Raipur) And Associated Hospital (Dr. B.R.A.M. Hospital, Raipur, C.G.). Descriptive Statistics And Correlational Test Were Used For Analysing The Data. Results: Total 245 Patients Were Selected, 232 Were Male (94.69%), 236 Were Married (96.3%), 129 Were Employed And Working As Unskilled Worker (52.7%). Most Common Complications Of ALD Includes Jaundice (69.4%) And Ascites (77.5%). The Amount Of Alcohol Consumed Was Significantly Associated With Ascites (P*<0.001), Jaundice (P*<0.009), Hepatorenal Syndrome (P*<0.002), MDF Score (P*<0.01), MELD Score (P*<0.00), Child Pugh Score (P*<0.00)1, And Also With Mortality (P*<0.04). The Duration Of Alcohol Consumption Was Significantly Associated With Ascites (P*<0.0001), Jaundice (P*<0.000), Hepatorenal Syndrome (P*<0.04), MDF Score (P*<0.0001) MELD Score (P*<0.0001), Child Pugh Score (P*<0.0001), And Mortality (P*<0.000). Conclusion: Duration And Amount Of Alcohol Consumption Play An Important Role In Development Of ALD And Correlated Well With The Prognostic Markers.
Authors and Affiliations
Dr. R. L. Khare1,, MD, Medicine, Dr. S. Parmawii2 MBBS
Keywords
Related Articles
- EP ID EP366019
- DOI 10.9790/0853-1703033841
- Views 60
- Downloads 0
Evaluation of the Efficacy and Safety of Intranasally Administered Ketamine and Midazolam for Paediatric Pre Medication
Objective: An evaluation of the efficacy and safety of intra nasally administered Ketamine and Midazolam for paediatric premedication. Materials and methods: The study was a prospective randomized double blind study invo...
Diabetes Disease Burden by Platelet Indices As Possible Biomarkers in Evaluation of Initial Vascular Risks in Grading Diabetes Mellitus Part I: Correlation of Platelet Dysfunction Indices With Hematopoietic and Biochemical Parameters
Diabetes disease burden in Diabetes mellitus was explored for its possible association with hematopoietic indices and serum predictors of hypertension with dyslipidemia. Hypothesis was that disease burden of diabetes is...
Atlanto-Axial Subluxation of the Cervical Spine As the Initial Presentation of Rheumatoid Arthritis : A Case Report
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affecting a significant percentage of the population. Rheumatoid arthritis synovitis affects mostly small hand and feet joints, although it may comprom...
A Rare Case Report on IgG4 Related Diseases
IgG4-related disease (IgG4-RD) is a newly recognized disorder, characterized by massive IgG4+ lymphocyte and plasma cell infiltration, storiform fibrosis, causing enlargement, nodules or thickening of the various organs,...
Canagliflozin – A Novel Oral Hyperglycemic Agent in The Fight Against Diabetic Mellitus
Canagliflozin, is a first-in-class,oral hypoglycemic drug to be approved by US FDA, that acts through inhibition of sodium glucose co- transporters in the renal tubules, resulting in glucosuria. Clinical trials with cana...