Clinical Profile of Alcoholic Liver Disease and Its Association with Pattern of Alcohol Consumption and Prognostic Markers
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Background: Alcoholic Liver Disease (ALD) Is A Severe Complication Related To Chronic And Excessive Alcohol Consumption And Includes A Spectrum Of Hepatic Lesions: Fatty Liver To Chronic Hepatitis. The Liver Injury Is A Complex Process, But The Quantity, Duration And Type Of Alcohol Intake Are The Most Important Risk Factors For ALD And Correlated Well With The Prognostic Markers. Early Acceptance Of Alcohol Abuse By The Patient And The Vigilance Of The Physician’s Toward Diagnosis Of Alcohol-Related Problems Is Requisite To Prevent Complications And Decreases Mortality. Aim: Present Study Aimed At Investigating The Association Of Type, Amount And Duration Of Alcohol Consumption With Clinical Profile Of Alcoholic Liver Disease And Comparison With The Prognostic Markers. Methods: The CrossSectional Study Design With Total 245 Patients Of ALD Were Selected In 23 To 67 Years Age Group, From Pt. Jawaharlal Nehru Memorial Medical College, Department Of Medicine, Raipur (C.G.) (Pt. JNM Medical College, Raipur) And Associated Hospital (Dr. B.R.A.M. Hospital, Raipur, C.G.). Descriptive Statistics And Correlational Test Were Used For Analysing The Data. Results: Total 245 Patients Were Selected, 232 Were Male (94.69%), 236 Were Married (96.3%), 129 Were Employed And Working As Unskilled Worker (52.7%). Most Common Complications Of ALD Includes Jaundice (69.4%) And Ascites (77.5%). The Amount Of Alcohol Consumed Was Significantly Associated With Ascites (P*<0.001), Jaundice (P*<0.009), Hepatorenal Syndrome (P*<0.002), MDF Score (P*<0.01), MELD Score (P*<0.00), Child Pugh Score (P*<0.00)1, And Also With Mortality (P*<0.04). The Duration Of Alcohol Consumption Was Significantly Associated With Ascites (P*<0.0001), Jaundice (P*<0.000), Hepatorenal Syndrome (P*<0.04), MDF Score (P*<0.0001) MELD Score (P*<0.0001), Child Pugh Score (P*<0.0001), And Mortality (P*<0.000). Conclusion: Duration And Amount Of Alcohol Consumption Play An Important Role In Development Of ALD And Correlated Well With The Prognostic Markers.
Authors and Affiliations
Dr. R. L. Khare1,, MD, Medicine, Dr. S. Parmawii2 MBBS
Keywords
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- EP ID EP366019
- DOI 10.9790/0853-1703033841
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