Clinical study of 3g/L sodium hyaluronate eye drops with bromhexine hydrochloride tablets for dry eye
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 4
Abstract
AIM:To investigate the clinical efficacy of 3g/L sodium hyaluronate eye drops combined with bromhexine hydrochloride tablets on the treatment of dry eye. <p>METHODS:Totally 200 patients with dry eye were randomly divided into the control group(<i>n</i>=100)and observation group(<i>n</i>=100). Patients in two groups were given 3g/L sodium hyaluronate eye drops and physiotherapy. On the basis of this, the observation group were treated with bromhexine hydrochloride tablets. The inflammatory factors(IL-6, IL-10, TNF-α and IL-1β)levels and ocular symptom scores(OSDI, BUT, SⅠt, FL)in the two groups were compared between before and after treatment. And the clinical efficacy and adverse reactions were evaluated. <p>RESULTS: After treatment, the IL-6, IL-10, TNF-α, IL-1β, OSDI and FL scores in two groups were significantly lower than those before treatment, and BUT and SⅠt were significantly higher than those before treatment. Moreover, the improvement degree of the above indexes in the observation group were better than those in the control group, showing statistically significant difference(<i>P</i><0.05). The total effective rate of the observation group was higher than that of the control group(<i>χ</i><sup>2</sup>=5.531, <i>P</i>=0.019), but there was no significant difference in the incidence of adverse reactions between the two groups(<i>χ</i><sup>2</sup>=0.307, <i>P</i>=0.579). <p>CONCLUSION:As for the patients with dry eye, the combination of 3g/L sodium hyaluronate eye drops with bromhexine hydrochloride tablets can significantly decrease the level of inflammatory factors, improve the eye symptoms and the clinical total efficiency, without increasing treatment-related adverse effects.
Authors and Affiliations
Hui-Qun Xu
Keywords
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- EP ID EP656169
- DOI 10.3980/j.issn.1672-5123.2018.4.28
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