Comparative Effect of Antidepressants (Duloxetine) and NSAID (Dexibuprofen) in a New Rat Model of Chronic Pain Induced Depression Associated with Monosodium Iodo Acetate (MIA) Induced Osteoarthritis in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 1
Abstract
Objective: To evaluate the role of anti-depressants (Duloxetine) and NSAID (Dexibuprofen) in a new rat model of chronic induced depression. Methods: Twenty four male wistar rats were divided into 4 groups of 6 animals each. Group I to IV served as vehicle control, osteoarthritis (OA) control, duloxetine and dexibuprofen treated groups respectively. Group I received intra-articular Injection of 50 µl of 0.9% normal saline, and Group II to IV received 50 µl MIA, and the treatment of drugs started on the same day. The animals will be monitored for OA parameters and/or depression on pre-dose day (day 0) and on day 1, 3, 5, 7, 11, 14, 18, 21 and 28 th day. Results and Discussion: In MIA treated group, the rise in knee inflammation is maximum on day 3 (12.31±0.85 mm; p<0.001) and reduced near to normal on day 7 (9.26±0.57 mm; p<0.001). Dexibuprofen and duloxetine decreased the inflammation from day 3, and the decrease is comparatively better in dexibuprofen group. Also, dexibuprofen increased vocalization threshold of knee compression force for 7 days and decreased thereafter, whereas duloxetine has no effect for first 7 days and increased thereafter. Duloxetine was significantly (p<0.001) effective on neuropathic pain (Punctate allodynia, mechanical gripstrength, threshold angle of knee extension) and depression (forced swim test and locomotor activity) compared to dexibuprofen. Conclusion: The present study has shown that dexibuprofen has the potential in the initial phase of chronic OA and duloxetine in the later stage, where neuropathic and depressive component dominates.
Authors and Affiliations
V. S. Saravanan, V. Krishnaraju
Keywords
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- EP ID EP344697
- DOI 10.9734/BJPR/2014/4040
- Views 88
- Downloads 0
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