Monitoring of Pesticide Poisoning in Different Occupational Groups by the Estimation of Serum Cholinesterase (PChE), ALT, AST & Bilirubin
Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 16, Issue 5
Abstract
Objectives: An increasing number of reports suggest that chemical and physical agents in the environment, introduced and spread by human activity may affect human liver. The present study was conducted to find out pesticide poisoning and its possible effect on liver by assaying PChE, ALT, AST & bilirubin in different occupational groups those are routinely exposed to pesticides. Materials and Methods: Epidemiological studies focusing on exposure to pesticide and its impact of poisoning in liver. A total of 75 adult males were included in the study. Study subjects/Pesticides sprayer were divided into three groups according to their occupations- working in vector control campaign (Group-A), Farmer (Group-B), Control (Group-C). Members of the first two groups are directly involved in pesticide preparation & spraying. Blood samples were collected from the study subjects by venipuncture and serum was separated and tested for PChE, ALT, AST and bilirubin by spectrophotometer. Results: In the present study the mean (± SD) of serum PChE in the Group-A and Group-B were found 4087.83 ± 1444.23 U/L and 8890.03 ± 2717.75 U/L respectively. In Group-C the mean (± SD) of serum PChE was 10357.92 ± 3106.02 U/L Decrease in PChE activity was observed in the occupationally exposed groups as compared to control group (One-way ANOVA; p < 0.000). The mean (± SD) of serum ALT in the Group-A, Group-B and Group-C was 21.76 ± 5.59 U/L, 13.88 ± 5.23 U/L, and 16.96 ± 6.25 U/L respectively. The mean (± SD) of serum AST in the Group-A and Group-B was 24.96 ± 4.06 U/L and 19.44 ± 4.88 U/L respectively. In Group-C the mean (± SD) of serum AST was 22.24 ± 6.11 U/L. Both the liver enzymes ALT and AST show a negative correlation to the PChE. But the ALT level was much higher in sprayer group and shows significant correlation with PChE (Spearman Correlation Coefficient, rs= -.619**, p < 0.001). The mean (± SD) serum bilirubin in the Group-A, Group-B and Group-C was 0.888 ± 0.422 U/L, 0.5120 ± 0.303 U/L and 0.644 ± 0.335 U/L respectively. Bilirubin level also shows a significant negative correlation with PChE activity in both Group-A and Group-B, rs= -0.560**, and rs= -0.627** respectively. Conclusions: Epidemiological studies suggest awareness of poisoning of pesticide an environmental factor that may affect biological system. Warning labels of pesticides fail to inform users of long-term health dangers. Research into the impact of pesticides on workers’ health, diagnostic tests would confirm overexposure to most classes of pesticides, reduced activity of PChE in occupationally exposed people was observed. An elevated level of liver enzymes and bilirubin was found also. Continuous and prolonged exposure to pesticides (organophosphorous) resulted in the decreased PChE activity and increased AST, ALT & bilirubin.
Authors and Affiliations
Hossen Mohammad Jamil, Mahamudul Haque, Md. Saidur Rahman, Talha Bin Emran, Rashedul Hasan Chowdhury, Farhana Nasrin, Chowdhoury Mohammad Monirul Hasan
Keywords
Related Articles
- EP ID EP312977
- DOI 10.9734/BJPR/2017/33468
- Views 75
- Downloads 0
Factors Predicting Erythropoietin Responsiveness among Maintenance Hemodialysis Patients: Prospective Longitudinal Study
Aim: To characterize the longitudinal hemoglobin (Hgb) variability in response to erythropoietin (Epo) and to identify the influence of clinical factors on Hgb level and Epo responsiveness in a sample of hemodialysis (HD...
Use of Mobile Phones for Monitoring Adverse Drug Reaction in Pharmacy and Drug Stores in Ishaka, Uganda - a Pilot Assessment of Willingness to Report
Aim: We investigated reporting of Adverse Drug Reaction (ADR) following use of drugs purchased from open system pharmacy (OSP) and drug stores, and the effectiveness of mobile phones for reporting drug reactions and dete...
Archachatina marginata Haemolymph Potentiates Hypoglycemic Effect by Mimicking Insulin in Streptozotocin-Induced Diabetic Rat
Aims: This study investigates the hypoglycemic potential of Archachatina marginata haemolymph and its mechanism in streptozotocin -induced diabetic rats. Study Design: One factor experimental design. Place and Duration o...
Pharmacological Study of Dopamine Receptors Agonist and Antagonist on Mouse Model of Myocardial Injury
Objective: The present study was designed to evaluate the potential protective effect of using mix of bromocriptine 7 mg/kg & metoclopromide 3 mg/kg on the inflammatory biomarkers AST, ALT and LDH1 against isoprotrenol-i...
Comparative Evaluation of Bioactivities of two Marine Sponges, Zygomycale parishii and Callyspongia diffusa from Southwest Coast of India
Aims: The present study was done to evaluate and compare the bioactivities of methanol and dichloromethane extracts of two marine sponges, Zygomycale parishii and Callyspongia diffusa from Southwest coast of India. Place...