Comparative Evaluation of Fourth Generation Fluoroquinolones with Fortified Cephazolin in the Treatment of Bacterial Corneal Ulcers
Journal Title: International Journal of Research and Review - Year 2018, Vol 5, Issue 6
Abstract
Purpose: To study efficacy of fourth generation fluoroquinolones versus conventional fortified cephazolin eye drops for the treatment of bacterial corneal ulcers. Method: 40 diagnosed cases of bacterial corneal ulcers were randomly allotted into two groups: Group 1 patients were treated using fortified cephazolin (50 mg/ml) and, group 2 with commercially available fourth generation fluoroquinolone-Moxifloxacin 0.5% eye drops. The response to treatments were analyzed according to the size of corneal ulcer and anterior chamber cell reaction at second and third weeks. Also size of the residual corneal opacity was analyzed after complete healing of corneal ulcer were compared. Data were statistically analyzed using appropriate test of significance using SPSS software (version16.0) Results: Data was statistically analyzed using t- test. In this study, both the groups were equally matched in terms of size of the ulcer and anterior chamber cell reactions, at the time of presentation with p- values 0.85 and 0.06. At 2 weeks after initializing the treatment, the difference in response to treatment in group 2 was statistically significantly better as compared to group 1 with p values of 0.008 and 0.0004 for corneal ulcer size and anterior chamber cell reactions, respectively. Similarly, with p< 10-6 for both at week 3 of treatment. Comparing the size of residual corneal opacity after complete healing of the corneal ulcers in group 2 was statistically significantly smaller as compared with group 1 with p=0.0004. Conclusion: The current study shows that treatment response of bacterial corneal ulcers with fourth generation fluoroquinolones is significantly better than conventional treatment with fortified cephazolin eye drops.
Authors and Affiliations
Dr. Smita Kishor Kadu
Keywords
Related Articles
- EP ID EP480731
- DOI -
- Views 69
- Downloads 0
The Rationality Assumption from Birth to Reincarnation
Being a very age old yet a dynamically modern social science, economics has journeyed a lot all throughout centuries. The birth dates back to Greeks before Socrates. All this while up until now many notions have seen a p...
Psychosocial Correlates of Recurrent Abdominal Pain in Paediatric Patients
Background: Recurrent abdominal pain (RAP) is a very common distressing complaint in the pediatric population. Etiology remains an enigma as in majority of the cases the cause is not identified and therefore these cases...
Effects of Tomato Extract (Lycopersicon Esculentum) on Carbimazole-Induced Alterations in Kidney of Albino Rats
Acute Kidney Injury has a very high mortality and morbidity despite advances in clinical treatment. The health benefits of tomato extract on kidney injury has not been extensively studied. This research investigated the...
Decision to Purchase Eco-Label Products: Case Study in Indonesia
Indonesia is a potential market for cosmetic products. The demand for cosmetics in Indonesia accounts for US $ 516.99 million. The potential of this cosmetic market is due to the increasing population of young people and...
Preparation and Characterization of Biodiesel (Fatty Acid Methyl Ester) From a Commercial (Soya Bean) Oil
In recent times, the world has been confronted with an energy crisis due to depletion of resources and increased environmental problems. This situation has led to the search for an alternative fuel, which should be not o...