Abstract

Background: A large number of patients are regularly attending the thyroid outdoor department. Many of them are suffering from complications of thyroid disorders. Oxidative stress among hyper and hypothyroid patients may be a causative factor for thyroid related complications. Materials and methods: 40 hyperthyroid, 40 hypothyroid and 40 age and sex matched control subjects were included in the study. Malondialdehyde, a lipid peroxidation product, and protein carbonyl, a protein oxidation product were estimated in them spectrophotometrically. Statistical analysis used- Is done by SPSS 20 software for windows. Results- ANOVA shows significant increase (p<0.001) of oxidative stress parameters among the three groups. Bonferroni correction reveals significantly higher values of those parameters in hyperthyroids from hypothyroid and control groups (p<0.001) The hypothyroid patients had also significantly higher values than controls (p<0.0001). Conclusion: Hyperthyroidism produces more oxidative stress than hypothyroidism. Assesment and control of oxidative stress at early stage of hyper and hypothyroidism can prevent or delay the grave consequences by the same

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