COMPARATIVE STUDY AND ANALYSIS OF RELEASE KINETICS OF CORIANDER FORMULATIONS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2013, Vol 3, Issue 12
Abstract
Acne is an inflammatory disease of sebaceous follicles of skin. The present study was conducted to formulate and evaluate the topical anti acne formulation of coriander oil and coriander aqueous extract with and without penetration enhancer. Then these formulations were compared with each other to establish the effect of penetration enhancer. The antibacterial activity of Coriander oil and aqueous extract against Propionibacterium acne (P.acne) and Staphylococcus epidermidis (S.epidermidis) was investigated by disc diffusion method and Minimum inhibitory concentration (MIC) by agar dilution method. The topical formulations were developed separately without penetration enhancer (menthol) and further two formulations were developed separately with penetration enhancer. These formulations were subjected to the drug content uniformity, invitro diffusion and skin permeation studies. The results showed that coriander oil possesses greater potency as compared to the aqueous extract as the MIC values of 1%v/v and 1.1%v/v were obtained for oil against P.acne and S. epidermidis respectively. The incorporation of penetration enhancer resulted in the formulations with increased drug content, invitro release and permeation. The statistical analysis showed that menthol incorporation led to the significant increase in the permeation of both types of formulations. All the formulations followed the first order release and higuchi model was found to be the most suitable one.
Authors and Affiliations
Aditi Vats, Pranav Sharma
Keywords
Related Articles
- EP ID EP223309
- DOI -
- Views 103
- Downloads 0
PROTEOMIC STUDIES OF CHEMICAL CONSTITUENTS OF COMMELINA COMMUNIS
The present research work was aimed to discover anti-viral and anti-dengue activity of the phytochemical constituents present in Commelina communis using Molecular docking studies. In this research work, we have screened...
LIQUID CHROMATOGRAPHY MASS SPECTROMETRIC METHOD FOR QUANTIFICATION OF POTENTIAL GENOTOXIC IMPURITY 2, 6-DIAMINOPYRIDINE IN MINODRONIC ACID
Abstract A new, simple, accurate and sensitive method was developed for the quantification of potential genotoxic impurity 2, 6-Diaminopyridine in Minodronic acid using Liquid Chromatographic Mass Spectrometry (LCMS). Th...
GENE THERAPY IN CANCER
Abstract Gene therapy is a kind of experimental technique that uses genes to treat or prevent disease. In the future, these methods may allow doctors to treat a disorder by inserting a gene into a patient’s as a alternat...
INCREASED RISK OF ENDOMETRIAL CARCINOMA AND ACCURACY IN THE DIAGNOSIS OF PATIENTS: A GYNECOLOGIC STUDY
In sharp difference to numerous other tumor sorts, the occurrence and mortality of endometrial disease keep on growing. This awful pattern is, in no little section, an aftereffect of the overall corpulence pandemic. The...
POTENTIAL ANTITUBERCULAR AND SAR STUDY OF SUBSTITUTED [2-(1-BENZOFURAN-2-YL) QUINOLIN-4-YL] METHANOL AND [2-(1-FURAN-2-YL) QUINOLIN-4-YL] METHANOL ANALOGUES
ndicating the importance of coupled heterocycles and their important role in the multitude progress of the diseases. In view of this, a series of [2-(1-benzofuran-2-yl) quinolin-4-yl] methanol and [2-(1-furan-2-yl) quino...