Comparative Study between the Effect of Topical Insulin and Normal Saline Dressing in Healing of Diabetic Foot Ulcers
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Numerous topical medication and gels are promoted for ulcer care and healing. Relatively few have proved to be more efficacious than saline wet to dry dressings. The present study was aimed to compare the effect of topical insulin and normal saline dressing in healing of diabetic foot ulcers. Material and methods: The present one year hospital based randomized controlled trial was conducted in the Department of General Surgery, Rangaraya medical college, Kakinada. A total of 60 patients with diabetic foot ulcers were studied. Based on the envelop method, patients were divided into two groups of 30 patients each that is group A (topical insulin) and group B (normal saline). Results: In this males (66.67% in group A and 83.33% in group B) outnumbered females in both the groups with male to female ratio of 2:1 in group A and 4:1 in group B. The mean age in group A was 52.00 ±11.00 years and in group B it was 57.00 ± 9.80 years (p=1.000). Among patients with group A significant reduction of mean ulcer area was observed (307.23 ± 169.87 mm2) with higher mean percentage reduction (35.19 ± 19.00 percent) whereas in group B the mean percentage reduction was significantly less (18.82 ± 4.06 percent) with less reduction of mean final ulcer area (149.90 ± 64.45 mm2) (p<0.001). Conclusion: Overall, topical insulin dressing provided favourable outcome in patients with diabetic foot ulcer by significant reduction in wound area when compared to normal saline dressing and it had positive role in reducing the wound infection if present.
Authors and Affiliations
K. Ramarao, L. Ramu
Keywords
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