COMPARATIVE STUDY OF INTRAVENOUS DEXMEDETOMIDINE AND INTRAVENOUS PROPOFOL INFUSION FOR MONITORED ANESTHESIA CARE IN PATIENTS UNDERGOING TYMPANOPLASTY UNDER LOCAL ANESTHESEIA.
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Background and Aim: To get ideal sedative state in patients undergoing surgery in local anesthesia is challenging for Anesthesiologist. Our aim was to evaluate efficacy of intravenous Dexmedetomidine and intravenous Propofol infusion in patients undergoing Tympanoplasty in local anesthesia for monitored anesthesia care. Material and Methods: Ninety patients were randomly divided into two groups of 45 each. Group D patients were given I.V. Dexmedetomidine on initial loading dose of 1 g/kg for 10 minutes period followed by 0.2-0.7 g/kg/hr. Patients in group P were given I.V. Propofol 75 g/kg/min for 10 minutes followed by maintenance dose of 12.5-75 g/kg/min. Sedation level of patients were recorded regularly using Ramsay Sedation Scale. Besides that pulse, blood pressure, respiratory rate, saturation, rescue analgesia and any untoward effect were noted. Result: Dexmedetomidine and Propofol provide adequate sedation needed for MAC, but Propofol require rescue analgesia in three patients. The onset and recovery from sedation were earlier with Propofol. Mean heart rate was lower in Dexmedetomidine group and blood pressure was lower in the Propofol group. Both the drug doesn’t affect respiration. Patients of Dexmedetomidine group develop dryness of mouth. Conclusions: Both Dexmedetomidine and Propofol were effective in providing monitored anaesthesia care, but Dexmedetomidine was found to be better drug as it provides hemodynamic stability, additional rescue analgesia and better sedation.
Authors and Affiliations
Dr. Sangeeta Bansal Agarwal
Keywords
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