Comparative study of transdermal nitro-glycerine versus oral nefidipine with respect to mean prolongation of pregnancy in preterm labour
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 4
Abstract
Background: Preterm labour is defined as the onset of labour after the age of viability (20-24weeks) and before 37 completed weeks of pregnancy and its incidence is 6-10% of all births in developed countries. Aims and Objectives: To Comparetransdermal nitro-glycerine versus oral Nefidipine with respect to mean prolongation of pregnancy in patients with preterm labour. Methodology: This randomized controlled study was conducted in the department of obstetrics and Gynaecology, SMGS Hospital, Jammu over period of one year. Fifty-seven patients presented with features of preterm labour during the said study period, but it was seen that out of these 57 patients, contractions subsided after 1 hours of bed rest and hydration in 4 patients, and 3 patients were lost to follow –up, hence were not the candidates for tocolytic therapy. Total of 50 patients were enrolled-25 were in transdermal nitroglycerine group (study group) and 25 in oral nifedipine group (control group). Descriptive statistics, that is mean, standard deviation and frequency distribution were calculated for each and every variable, wherever applicable, to see significant difference between the groups according to the different categories. For the continuous variable, student ‘t’-test (unpaired) was applied and to see for the association among the variables, chi-square test was used. ‘p’-value of <0.05 was considered as level of statistical significance. SPSS version 7.5 was used for statistical analysis. Result: The age of patients in the present study ranged from 20 to 32 years. The mean age of the study group was 25.28±3.16 years, and of the control group was 25.84 ± 4.27 and was not statistically significant. Parity: the mean parity of the study group was 1.04± 1.27 and of the control group 0.84±0.68. The difference between the two groups was not statistically significant. Fourteen (56%) women in the study group are multiparous as compared to 17 (68%) in the control group. Previous preterm delivery: two (8%) women in the study group had previous preterm birth as compared to 3(12%) women in the control group. Statistically, the difference was non-significant Pregnancy was prolonged by 28.56 ± 22.89 days in the study group and by 21.78±22.95 days in control group (p=0.311). Mean gestation at delivery in the study group was 35.58±2.59 weeks and in the nifedipine group 34.91±2.825 weeks. Seven women (28%) in the study group and 11 (44%) in the control group delivered within one week of the randomization (p=0.15). the number of women delivered by 34th week, between 34th and 37th week and after 37th week gestation were 10 (40%), 9 (36%) and 6 (24%) in the study group and 12 (52.17%), 5 (21.73%) and 6(26.08%) in the control group, respectively. The percentage prolongation of gestation in the study group was 89.86±57.98% as compared to 85.25±51.52% in the control group (p=0.77) which was not statistically significant. Conclusion: Pregnancy was prolonged by atleast 48 hours in 92% of women in nitroglycerine group and 86.9% of women in nifedipine group.
Authors and Affiliations
Anuradha 1, Bhanu Mahajan
Keywords
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