Comparative Study To Evaluate The Effect Of Zolendronic Acid And Teriparatide On Bone Mineral Density In The Treatment Of Osteoporosis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background: Osteoporosis is a systemic metabolic bone disease which is characterized by low bone mass and deterioration of bone micro-architecture, resulting in increased susceptibility to fractures. The pathological fracture due to osteoporosis is a serious medical problem and a notable burden on the health care system. Many patient will experience significant functional loss, poor health –related quality of life and higher mortality rate. Many breakthroughs have been made in order to prevent osteoporotic fracture and improve the quality of life. However, today, a completely safe, effective and generally accepted treatment for osteoporosis has not been defined yet. Objectives: This study is under taken to compare the effect of zolendronic acid and teriparatide on bone mineral density in the treatment of osteoporosis. Methods: 60 patient who attended Orthopedics department, RIMS, Imphal, during May 2015 to May 2017 and who fulfilled the inclusion criteria were included in the study, irrespective of sex and randomly divided into two group (30 patient each). Group-I was treated with zolendronic acid and Group-II was treated with teriparatide with equal amount of supplemental calcium and calcitriol. BMD by Dexa-scan was measured at the start of therapy, 6 months and 12 months after therapy. Statistical analysis was done using independent T-test value and results compared. Result: The mean Tscore of the zolendronic acid group (group I) and teriparatide group (group II) at the start of therapy was - 3.47±0.45 and -3.40±0.49. The mean T-score of zolendronic acid group and teriparatide group after 6 month of therapy was -2.47±0.44 and -2.46±0.43. The mean T-score of zolendronic acid group and teriparatide group after 12 months of therapy was -2.01±0.46 and -1.39±0.40. Conclusion: Teriparatide results in better improvement of bone mineral density with better clinical improvement and less side effect compared to zolendronic acid.
Authors and Affiliations
Dr. Dilip Soring, Prof. S. N. Chishti, Prof. A. Mahendra Singh, Dr. Shams Gulrez, Dr. B. Punithavasanthan, Dr. Rajkumar Debbarma, Dr. Prabhu Shrinivas Prashanth, Dr. Temjensunep, Dr. Trinajit Debbarma
Keywords
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- EP ID EP244338
- DOI 10.9790/0853-1610080611
- Views 38
- Downloads 0
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