COMPARING HIGH INTENSITY WITH LOW INTENSITY STATINS IN ACHIEVING OPTIMAL LDL GOALS AMONG CORONARY ARTERY DISEASE PATIENTS IN SUBURBAN POPULATION IN SOUTH INDIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 6
Abstract
BACKGROUND Patients with ischemic heart disease (IHD), including those with an acute coronary syndrome (ACS), should receive long-term, intensive lipid-lowering statin therapy. Target levels of low-density lipoprotein cholesterol (LDL-C) in patients with ACS are <70 mg/dl. Various studies have demonstrated that many high-risk patients do not achieve optimal LDL-C control in spite of being on adequate dose of lipid-lowering statin therapy. The aim of the present study was to analyse the control of LDL-C and high-density lipoprotein (HDL-C) levels after 12 weeks of statin therapy at different doses, in patients who had ACS and who underwent revascularization with or without a prior episode of ACS. MATERIALS AND METHODS This was a prospective cohort study. 100 consecutive cases diagnosed with ACS or those who underwent coronary intervention with or without prior ACS were enrolled. These patients were initiated on either atorvastatin (ATV; doses ranging from 10 mg to 80 mg) or rosuvastatin (RSV; 5 mg to 20 mg), according to initial LDL-C values at index point of contact. Continuous Variables are presented as mean ± SD and were compared using one-way ANOVA. Comparison of each class of patients according to the respective doses of statins and the degree of lowering of LDL-C after 12 weeks of treatment was done. RESULTS Majority of patients were male (80%). ATV40 demonstrated significant change in LDL-C, HDL-C and TC. ATV20 produced significant change in both LDL-C and TC, while ATV10 demonstrated significant change only in TC. Furthermore, only 69% of the people received high-dose of statin. More than 80% of the patients using high-dose stains (i.e., ATV40, ATV80 and RSV20) achieved optimal LDL-C control. In patients taking low-dose statin, more than 50% people did not achieve optimal LDL-C control. CONCLUSION Patients with CAD who were not receiving adequate dose of lipid lowering statin therapy, did not achieve optimal LDL-C control. Among these, patients treated with high-dose statins (ATV40, ATV80 and RSV20) achieved optimal LDL-C control and patients who received low-doses of statins did not acquire optimal LDL control and thus are further prone to adverse coronary events.
Authors and Affiliations
Vinodkumar Balakrishnan, Ramesh Sankaran, Thanikachalam S, Muralidharan T. R, Nagendra Boopathy Senguttuvan, Dasarath Boppana
Keywords
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- EP ID EP554767
- DOI 10.14260/jemds/2019/80
- Views 45
- Downloads 0
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