Comparison of antiinflammatory activity of Artemisia annua leaves extracts obtained through conventional and new method.
Journal Title: Journal of Pharmacy Research - Year 2009, Vol 2, Issue 1
Abstract
In this study, the antiinflammatory activity of Artemisia annua leaves aqueous methanolic extracts (obtained through the Soxhlet and MAE) were studied using carrageenan and egg albumin induced rat paw edema in acute, and cotton pellets and grass pith induced chronic inflammation models. The extract (obtained through the MAE) at a dose of 200gm/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract (obtained through the MAE) exhibited maximum antiinflammatory effect, that is 55.44 and 53.16% at the end of 5h with carrageenan and egg albumin induced rat paw edema, respectively. In chronic model the extract (obtained through the MAE) at a dose of 200mg/kg showed 60% reduction in granuloma weight. The effect produced by the extract was comparable to that of Diclofenac Sodium, a non-steroidal antiinflammatory agent. Phytochemical results suggested that the triterpenoids, flavonoid, polyphenols and coumarin present in the plant extract inhibit the development of maximum edema response in acute and chronic models.
Authors and Affiliations
Swapnadeep Parial* , D. Jain , S. Joshi
Keywords
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