Comparison of Different Doses of Intravenously Administered Dexmedetomidine with Fentanyl on Haemodynamic Response To Intubation in Patients Undergoing Surgery under General Anesthesia
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Background: Laryngoscopy and intubation are associated with a sympathetically mediated circulatory response due to irritation of respiratory tract which is associated with increase in pulse rate and blood pressure that may be dangerous. Objective: The aim of the present study was to determine and compare of different doses of intravenously administered dexmedetomidine with fentanyl on haemodynamic response to intubation in patients undergoing surgery under general anesthesia. Methods: 90 patients ASA1, ASA2 scheduled to undergo elective and emergency surgery under general anaesthesia were enrolled in double blind prospective randomized controlled trial. They were randomly allocated to one of the following groups. Group A received 2 micro gram/kg fentanyl intravenously10 minutes before induction. Group B received 2 micro gram/kg fentanyl and 0.5 microgram/kg dexmedetomidine intravenously 10 mins prior to induction. Group C received 2 mico gram/kg fentanyl and 1 microgram/kg dexmedetomidine i.v. 10 minutes prior to induction. Results: The two groups were comparable in their demographic profiles. Both study groups (B & C) were comparable with respect to their heart rate at base line, 1 minute, 2 minutes, 5 and 10 minutes after inhalation. Group C (Dexmedetomidine 1μg) demonstrated a greater suppression of chronotropic response to intubation as compared together two groups. Both the groups (B & C) were comparable to their SBP at base line, 2, 5 and 10 minutes. Group C demonstrated a better suppression of the pressor response to intubation compared to other two groups.
Authors and Affiliations
Sandeep Kothari, Priyanka Saini, Anita Kothari, Gaurav Sharma
Keywords
Related Articles
- EP ID EP530250
- DOI 10.21276/ijmrp.2018.4.1.084
- Views 60
- Downloads 0
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