Comparison of Different Doses of Intravenously Administered Dexmedetomidine with Fentanyl on Haemodynamic Response To Intubation in Patients Undergoing Surgery under General Anesthesia
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Background: Laryngoscopy and intubation are associated with a sympathetically mediated circulatory response due to irritation of respiratory tract which is associated with increase in pulse rate and blood pressure that may be dangerous. Objective: The aim of the present study was to determine and compare of different doses of intravenously administered dexmedetomidine with fentanyl on haemodynamic response to intubation in patients undergoing surgery under general anesthesia. Methods: 90 patients ASA1, ASA2 scheduled to undergo elective and emergency surgery under general anaesthesia were enrolled in double blind prospective randomized controlled trial. They were randomly allocated to one of the following groups. Group A received 2 micro gram/kg fentanyl intravenously10 minutes before induction. Group B received 2 micro gram/kg fentanyl and 0.5 microgram/kg dexmedetomidine intravenously 10 mins prior to induction. Group C received 2 mico gram/kg fentanyl and 1 microgram/kg dexmedetomidine i.v. 10 minutes prior to induction. Results: The two groups were comparable in their demographic profiles. Both study groups (B & C) were comparable with respect to their heart rate at base line, 1 minute, 2 minutes, 5 and 10 minutes after inhalation. Group C (Dexmedetomidine 1μg) demonstrated a greater suppression of chronotropic response to intubation as compared together two groups. Both the groups (B & C) were comparable to their SBP at base line, 2, 5 and 10 minutes. Group C demonstrated a better suppression of the pressor response to intubation compared to other two groups.
Authors and Affiliations
Sandeep Kothari, Priyanka Saini, Anita Kothari, Gaurav Sharma
Keywords
Related Articles
- EP ID EP530250
- DOI 10.21276/ijmrp.2018.4.1.084
- Views 62
- Downloads 0
Role of Laparoscopy, SSG and HSG in the Diagnosis of Tubal Factors of Infertility
Background: Female infertility is a condition of a woman who in ordinary favorable circumstances for breeding adds not even one to the population or produces no living or viable child. Hysterosalpingography gives informa...
The Pattern of Histopathology of Gall Bladder of Patients Undergoing Cholecystectomy
Background: Cholecystitis accounts for high mortality and morbidity, with most appropriate treatment being surgical removal of the gallbladder. There seems to be specific need for histopathology of gall bladder, as selec...
Transient Effect of Slow and Deep Breathing Exercise on Cardiopulmonary Functions
Introduction: In recent years, there has been considerable interest in scientific research on yoga which is being practice to decreases the effect of stress and strain on body and mind. Concentrating more towards the mod...
The Most Frequently Isolated Microorganisms and the Incidence of Positive Culture Report in Patients with Sepsis: A Hospital Based Prospective Study
Background: There are many diagnostic tests to rule out the presence or absence of sepsis but blood culture remain the key test for estimating the presence of sepsis. Until recently no biomarker has been able to help dif...
Clinicopathological Study of CNS Tumors in Ajmer Region
Objective: The aim of this study was to observe recent incidence of different CNS tumors and to study clinical and histopathological spectrum in Ajmer region. Methods: In two year retrospective study, from January 2014 t...