Comparison of Different Doses of Rocuronium for Endotracheal Intubation
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Rocuronium is an intermediate acting NDMR with rapid onset of action. The aim of this prospective, randomized, double blind study was to assess and compare the time of onset, duration of action and intubating conditions with three different doses of rocuronium bromide (0.6 mg/kg, 0.9 mg/kg, 1.2 mg/kg). Material and Methods: The anaesthesia was induced with injection propofol (till apneia appear). After 60 sec, nondepolarizing muscle relaxant rocuronium bromide was administrated intravenously. Patients were randomly allocated into three groups according to dose of Rocuronium (0.6 mg/ kg, 0.9 mg/kg and 1.2 mg/kg). Jaw relaxation, vocalcord position, motor response to intubation and overall intubating conditions were assessed. Results: Excellent intubating conditions were seen in 50, 70% and 90% of the patients after 0.6 mg/kg, 0.9mg/kg, 1.2 mg/ kg of Rocuronium respectively: P<0.05. Onset of action and duration of action were dose dependant. Conclusion: Rocuronium bromide in a dose of 1.2 mg/kg IV has rapid onset of action, longer duration and excellent intubating conditions in comparison to 0.9 mg/kg and 0.6 mg/kg dose at 60 seconds. So it can be used for intubation in emergency intubating conditions and where succinylcholine is contraindicated.
Authors and Affiliations
Neena Raizada, Gaurav . , Manoj Kumar Yadav, R. B. Singh, T. Prabhakar
Keywords
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