Comparison of HIV Screening Methods of Donor Blood Using Rapid Fourth Generation Elisa Assay in Kaduna, Nigeria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
The risks of transmitting HIV infection in blood transfusion can be reduced by improved donor selection and improved method of screening, which is able to reduce the diagnostic window between the time of Human Immunodeficiency Virus (HIV) infection and laboratory diagnosis. Fourth-generation Enzyme-Linked Immunosorbent assays (ELISA) for the combine detection of HIV antigen and antibody were compared to Rapid assays which detect antibody only. A total of 300 negative sera collected from four different hospitals were rescreened using ELISA, out of which 12 of the negative sera tested positive giving prevalence of 4%. 1 (2.77%) were positive from 36 negative sera, 10(5.8%) were positive from 171 sera, 1(1.36%) were positive from 73 negative sera and none was positive from 20 negative sera. The results show that overall HIV combine antigen/antibodies assays present better performance when compared to antibody only assays.
Authors and Affiliations
O. U. Daudu, M. Ajiboye, S. Ajal, A. S. Buru
Keywords
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- EP ID EP597457
- DOI 10.9790/0853-1605063435.
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