Comparison of Intraocular Pressure Fluctuations Measured by Goldmann Applanation Tonometer and Pulsatile Ocular Blood Flow Analyser
Journal Title: International Journal of Biomedical Science (IJBS) - Year 2006, Vol 2, Issue 4
Abstract
Evaluation of the effect of glaucoma medication is restricted by measurement of IOP as a dynamic physiological parameter. Present paper aimed to compare IOP fluctuations over time using Goldmann applanation tonometry (IOP-GAT) and pulsatile ocular blood flow analyzer (IOP-POBFA) under the apropos treatment regimes. Prospective 1 year follow-up study comprised of 30 patients of open angle glaucoma (60 eyes): 16 patients (32 eyes) receiving dorzolamide/timolol fixed combination (D/T) and 14 (28 eyes) latanoprost 0.005%. After 1 year follow-up D/T and latanoprost results referred to statistically significant tachyphylaxis effect, i.e. IOP-GAT increased in 2.31mmHg with D/T (p=0.007) and 2.72mmHg (p=0.004) with latanoprost and IOP-POBFA increased in 1.74mmHg (p=0.026) and 3.13 mmHg (p=0.007) respectively. Observed tachyphylaxis effects after 1 year under both treatment regimes should be assessed with respect to patient compliance and persistence to treatment. How to cite this article: Int. J. Biomed. Sci. 2006; 2(4):427-432 For full text article or PDF file, visit: www.ijbs.org
Authors and Affiliations
Ieva Sliesoraityte, Loreta Kuzmien, Ingrida Januleviciene
Keywords
Related Articles
- EP ID EP82658
- DOI -
- Views 102
- Downloads 0
Clinical Outcome of High Risk Gastrointestinal Stromal Tumor in a Meckel’s Diverticulum
We describe a seven years follow-up of a high risk gastrointestinal stromal tumor in a Meckel’s diverticulum in a 68-year-old man with abdominal pain and vomiting. The patient was operated in emergency for peritonitis du...
Synthesis of Some New 3, 5-Bis (substituted) Pyrazoles and Isoxazoles Based on (N’1E, N’3E)- N’1, N’3-Bis (3, 4, 5-substitutedbenzlidene) Malonohydrazide under Solvothermal Conditions
Synthesis of pyrazole and isoxazole derivatives has been a subject of consistent interest because of the wide applications of such heterocycles in pharmaceutical as well as agrochemical industry. Numerous compounds conta...
Sildenafil Inhibits the Proliferation of Cultured Human Endothelial Cells
The proliferation of endothelial cells plays a crucial role in the development of intraplaque angiogenesis (IPA). IPA is a major source of intraplaque hemorrhage and therefore contributes to the destabilization of athero...
Biomaterials in Maxillofacial Surgery: Membranes and Grafts
Today, significant differences in the use of biomaterials (membranes and grafts) of animal or synthetic origin have yet to be reported. Nevertheless, some evidences suggest that synthetic materials have a lower risk of d...
Characterization of Molecular Evolution in Multi-Drug Resistant of Mycobacterium tuberculosis by rpoB Gene in Patient with Active Pulmonary Tuberculosis from Iranian Isolates
This is the first genetic biodiversity study of Mycobacterium tuberculosis in Iran. Thus, we investigated the genetic patterns of strains isolated in the first survey of anti-tuberculosis drug-resistance by rpoB gene as...