Comparison of Pharmacokinetics Profiles 0.5% Bupivacaine of Normal Pregnant Patients and Preeclampsia Patients Undergoing Sectio Caesarea at dr. Sardjito Hospital Yogyakarta
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2017, Vol 6, Issue 1
Abstract
In preeclampsia pregnancy, there is a decrease in glomerular filtration and plasma protein. This study was conducted on 5 patients with normotensive pregnancy and sectio caesarea with preeclampsia pregnancy used of bupivakain 0,5% dose of 75 mg. Blood was collected as much as 3 cc at minute 0; 15’;20’;25’;30’;45’;60’;90’, through a vein and set the levels of bupivacaine by using High Performance Liquid Chromatography (HPLC). The value of bupivacaine pharmacokinetic profile (AUC (Area Under the Curve), AUMC (Area Under Concentration Moment), MRT (Mean Time Resident)) were calculated based on the levels of bupivacaine in the blood versus the time with noncompartement models, and then were analyzed with statistical test. The result showed that the value of AUC(0–~); value of AUMC(0–~); value of MRT on average for patients with normal pregnancy and preeclampsia pregnant patients respectively were 109.56±9.22 μg.mL-1.minute and 133.78 ± 25.47 μg.mL-1.minute; 6,956.41 ± 2,559.99 µg/mL.minute2 and 11,085.74±5733,94 µg/mL.minute2; 64.06±25.70 minutes and 110.45± 78.30 minutes. Statistical analysis results showed that the value of AUC(0–~), AUMC(0–~), and MRT at bupivacaine had no significant difference (p>0.05).
Authors and Affiliations
Helmina Wati, Dita A. D. Sandi
Keywords
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- EP ID EP369562
- DOI 10.15416/ijcp.2017.6.1.32
- Views 83
- Downloads 0
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