Comparison of Safety and Efficacy of Streptokinase and Tenecteplase in Patients of Myocardial Infarction
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Myocardial infarction is a major cause of mortality and morbidity worldwide. STEMI [ST segment elevation myocardial infarction] is a medical emergency condition. Reperfusion therapy like PCI [Percutaneous Coronary Intervention] is the gold standard for an early management of STEMI, which is better replaced by thrombolytic therapy. Thrombolytics available to treat STEMI include streptokinase (SK), urokinase (u-PA), alteplase (rt-PA), reteplase (r-PA), tenecteplase (TNK-tPA), lanoteplase.[3] Successful reperfusion therapy mainly depends upon the choice of thrombolytic agent. The aim of the study was to compare the safety and efficacy of Streptokinase and Tenecteplase in patients with acute ST segment elevation myocardial infarction. Time taken for drug administration after onset of symptoms and to assess the safety and efficacy of thrombolytics. Prospective observational study conducted for 6 months among 70 patients in cardiac care unit in Rajiv Gandhi Institute of medical sciences. Data was collected from the patients who are diagnosed with ST segment elevated myocardial infarction and who are prescribed either with streptokinase or tenecteplase. Microsoft excel was used for recording and analysing the data of recruited subjects. Descriptive statistics mean was used to calculate the average age and length of stay. Graph pad prism version 7.03(Chi-square test) was used to assess the level of significance between various parameters between the streptokinase and tenecteplase. Elderly patients more than 45 years and males were more prone to STEMI. As window period increases the thrombolytic efficacy decreases. The safety and efficacy were more for tenecteplase when compared to streptokinase. Hospital stay was increased for the streptokinase treated patients. Tenecteplase had minimum occurrence of ADR’s, greatest ST segment resolution, better symptomatic relief when compared to streptokinase. So that streptokinase was completely replaced by tenecteplase, further studies may require in cost reduction. Tenecteplase was the most safest and efficacious thrombolytic drug when compared to streptokinase in the treatment of STEMI. Co-morbidities did not affect the ST segment resolution in both thrombolytic drugs. The thrombolytic drug should be administered <2 hours of onset of symptoms for better resolution.
Authors and Affiliations
ChandraBabu . S, Gopinath. Chakka, Giri Raja Sekhar. Dornadula, Poojitha. Gundlapalli, Ramya. Nuthalapati, Yamuna. Manupoti
Keywords
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- EP ID EP441047
- DOI 10.9790/0853-1801121418.
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