Comparison of Serum Levels of Tumor Necrosis Factor Alpha (TNF-α) in Batak Male Schizophrenic Patients Versus Healthy Controls
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 2
Abstract
Schizophrenia is a common psychotic disorder, with a risk of about 1%, the etiology of schizophrenia unknown, one of which includes immunological disorders. Although, there are conflicting results, most studies focusing on plasma levels or the production of mitogen-stimulated cytokines. Furthermore, this study compared serum levels of TNF-α in male chronic schizophrenic patients and healthy control. Methods: This cross-sectional study was conducted on 40 male patients diagnosed with chronic schizophrenic and 40 healthy control. Severity illness was assessed with PANSS. Serum levels of TNF-α were measured by Quantikine HS Human TNF-α Immunoassay. Results: TNF-α levels were significantly higher in chronic schizophrenic (25.12±1.76) to healthy control subjects (5.49±1.69), p=0.001; p<0.05. Conclusions: This study suggests that TNF-α play a role in the immunopathogenesis of schizophrenia and behavioral changes. The relationship between schizophrenia and inflammation is supported by the production of abnormal cytokines.
Authors and Affiliations
Rona Hanani Simamora, Bahagia Loebis, Muhammad Surya Husada
Keywords
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- EP ID EP671095
- DOI 10.21276/ijlssr.2018.4.2.6
- Views 91
- Downloads 0
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