COMPARISON OF THE CYTOTOXIC EFFECTS OF UMBELLIPRENIN AND AURAPTENE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 1
Abstract
Umbelliprenin and auraptene structurally belong to the class of coumarins. Umbelliprenin can be synthesized chemically or extracted by maceration at room temperature. Various biological effects for both umbel lip renin and auraptene have been reported. One of their most important effects is cytotoxicity. This finding has increased interest in the application of umbelliprenin and auraptene as novel chemotherapeutic agents. In several studies, umbelliprenin and auraptene were successfully evaluated for anti-cancer effect. Moreover, mechanistic studies have attempted to find the mechanism of action of umbelliprenin and auraptene. In this review, we describe the cytotoxic effects of umbelliprenin and auraptene and compare them with each other. Umbelliprenin and auraptene share some cytotoxic and apoptotic induction properties but have differences in the suggested mechanisms.Â
Authors and Affiliations
Omid Gholami, Jamal Shamsara
Keywords
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