Comparison of two different doses of injection esmolol on haemodynamic response and seizure duration during electroconvulsive therapy

Abstract

Introduction-This study was aimed to compare the effects of two different doses of injection esmolol on haemodynamic response during ECT. Also the effects of esmolol pre-treatment on seizure duration, duration of anaesthesia and duration of recovery from anaesthesia and adverse effects if any were observed. Methods -Total 40 patients of ASA I or II posted for ECT were each studied thrice during three consecutive ECT treatments. Hence total of 120 ECT exposures studied. Three groups were formed Group P received placebo; Group E1 and E2 received intravenous esmolol 12.5mg and 25 mg bolus before ECT. Heart rate (HR), systolic and diastolic blood pressure (SBP/DBP) was recorded pre-bolus and every minute for 5 min and then 10, 15, 20, 25 & 40 minutes post-bolus. Duration of seizure, duration of anaesthesia, recovery and incidence of side effects were noted. Results- HR, SBP and DBP increased significantly in placebo group; at 5 minutes post ECT, HR in P, E1 and E2 group was (mean 145.20 ± 18.67,128.98 ± 17.72, 121.75 ± 18.38); SBP was (mean 168.85 ± 10.29, 152.88 ± 14.16, 143.90 ± 12.91) and DBP was (mean 114.45 ± 6.52, 103.35 ± 8.45, 93.05 ± 9.34) Superior hemodynamic stability was found in E2. Duration of seizure (P=0.952), duration of anaesthesia (P=0.437) and recovery (P= 0.792) had no effect of esmolol pre-treatment. No side effects were found in any of the study groups. Conclusion- Esmolol 25mg pre-treatment has stable haemodynamic results and no effect on seizure duration thus therapeutic outcome of ECT is not affected.

Authors and Affiliations

Dr. Vaijayanti Nitin Gadre

Keywords

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  • EP ID EP506541
  • DOI -
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How To Cite

Dr. Vaijayanti Nitin Gadre (2018). Comparison of two different doses of injection esmolol on haemodynamic response and seizure duration during electroconvulsive therapy. International Journal of Medical Science and Innovative Research (IJMSIR), 3(5), 271-279. https://europub.co.uk/articles/-A-506541