Comparison of two different doses of injection esmolol on haemodynamic response and seizure duration during electroconvulsive therapy
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
Introduction-This study was aimed to compare the effects of two different doses of injection esmolol on haemodynamic response during ECT. Also the effects of esmolol pre-treatment on seizure duration, duration of anaesthesia and duration of recovery from anaesthesia and adverse effects if any were observed. Methods -Total 40 patients of ASA I or II posted for ECT were each studied thrice during three consecutive ECT treatments. Hence total of 120 ECT exposures studied. Three groups were formed Group P received placebo; Group E1 and E2 received intravenous esmolol 12.5mg and 25 mg bolus before ECT. Heart rate (HR), systolic and diastolic blood pressure (SBP/DBP) was recorded pre-bolus and every minute for 5 min and then 10, 15, 20, 25 & 40 minutes post-bolus. Duration of seizure, duration of anaesthesia, recovery and incidence of side effects were noted. Results- HR, SBP and DBP increased significantly in placebo group; at 5 minutes post ECT, HR in P, E1 and E2 group was (mean 145.20 ± 18.67,128.98 ± 17.72, 121.75 ± 18.38); SBP was (mean 168.85 ± 10.29, 152.88 ± 14.16, 143.90 ± 12.91) and DBP was (mean 114.45 ± 6.52, 103.35 ± 8.45, 93.05 ± 9.34) Superior hemodynamic stability was found in E2. Duration of seizure (P=0.952), duration of anaesthesia (P=0.437) and recovery (P= 0.792) had no effect of esmolol pre-treatment. No side effects were found in any of the study groups. Conclusion- Esmolol 25mg pre-treatment has stable haemodynamic results and no effect on seizure duration thus therapeutic outcome of ECT is not affected.
Authors and Affiliations
Dr. Vaijayanti Nitin Gadre
Keywords
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